Exon Recognition in Vertebrate Splicing

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Prediction of human mRNA donor and acceptor sites from the DNA sequence

1991 • 798 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

A survey on intron and exon lengths

1988 • 569 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Splicing signals inDrosophila: intron size, information content, and consensus sequences

1992 • 380 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

In vitro polyadenylation is stimulated by the presence of an upstream intron.

1990 • 313 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

Construction of a novel database containing aberrant splicing mutations of mammalian genes

1994 • 293 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Selection of splice sites in pre-mRNAs with short internal exons.

1991 • 224 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

The human U1 snRNP-Specific U1A protein inhibits polyadenylation of its own pre-mRNA

1993 • 206 citations

Effect of 5' splice site mutations on splicing of the preceding intron.

1990 • 200 citations

Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

1991 • 200 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

Control of Alternative Splicing by the Differential Binding of U1 Small Nuclear Ribonucleoprotein Particle

1991 • 191 citations

The Cardiac troponin T Alternative Exon Contains a Novel Purine-Rich Positive Splicing Element

1993 • 189 citations

The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition.

1994 • 188 citations

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

1994 • 186 citations

Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation.

1991 • 184 citations

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

1987 • 179 citations

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

1993 • 173 citations

Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

1992 • 171 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

1991 • 146 citations

Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.

1994 • 146 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

Association with terminal exons in pre-mRNAs: a new role for the U1 snRNP?

1993 • 121 citations

Preferential excision of the 5' proximal intron from mRNA precursors with two introns as mediated by the cap structure.

1987 • 114 citations

The spliceosome assembly pathway in mammalian extracts.

1992 • 111 citations

Intron Definition in Splicing of Small Drosophila Introns

1994 • 110 citations

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.

1994 • 107 citations

A sequence compilation and comparison of exons that are alternatively spliced in neurons

1994 • 105 citations

Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing

1989 • 101 citations

An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.

1993 • 98 citations

A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA.

1994 • 95 citations

Cooperation of Pre-mRNA Sequence Elements in Splice Site Selection

1992 • 90 citations

In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit.

1993 • 80 citations

Structure and methylation of the human calcitonin/α-CGRP gene

1989 • 79 citations

Splicing Mutants and Their Second-Site Suppressors at the Dihydrofolate Reductase Locus in Chinese Hamster Ovary Cells

1993 • 77 citations

Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements.

1993 • 68 citations

Fission yeast gene structure and recognition

1994 • 62 citations

Species-specific signals for the splicing of a short Drosophila intron in vitro.

1993 • 50 citations

RNA 3' ends: formation and function--meeting review

1994 • 48 citations

Combinatorial splicing of exon pairs by two-site binding of U1 small nuclear ribonucleoprotein particle.

1991 • 42 citations

Alternative splicing of β-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5′- and 3′-splice sites of the nonmuscle/smooth muscle exon 6

1994 • 37 citations

Large exon size does not limit splicing in vivo.

1994 • 29 citations