Effects of RNA secondary structure on alternative splicing of Pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase?

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Nucleotide sequence of bacteriophage λ DNA

1982 • 1,171 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

A developmentally regulated activity that unwinds RNA duplexes

1987 • 439 citations

Heterogeneous Nuclear Ribonucleoproteins: Role in RNA Splicing

1986 • 399 citations

Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA

1986 • 389 citations

Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity

1987 • 320 citations

DNA sequences necessary for transcription of the rabbit β-globin gene in vivo

1982 • 298 citations

Alternative splicing caused by RNA secondary structure

1985 • 274 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

Comparison of Total Sequence of a Cloned Rabbit β-Globin Gene and Its Flanking Regions with a Homologous Mouse Sequence

1979 • 256 citations

Structure and Function of Nuclear and Cytoplasmic Ribonucleoprotein Particles

1986 • 243 citations

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene

1983 • 235 citations

5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU

1987 • 206 citations

Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression

1987 • 204 citations

RNP particles at splice junction sequences on Drosophila chorion transcripts

1985 • 191 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

Trans splicing of mrna precursors in vitro

1985 • 180 citations

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

1987 • 179 citations

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

1987 • 174 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

Complete nucleotide sequence of the fast skeletal troponin T gene

1986 • 146 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

Cell cycle expression of RNA duplex unwindase activity in mammalian cells.

1988 • 125 citations

Inverted repeat sequences in the drosophila genome

1975 • 121 citations

Factors influencing alternative splice site utilization in vivo.

1987 • 120 citations

5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole Inhibits Initiation of Nuclear Heterogeneous RNA Chains in HeLa Cells

1976 • 106 citations

Transcription of human histone genes in extracts from synchronized HeLa cells.

1984 • 97 citations

Structure of nuclear ribonucleoprotein: heterogeneous nuclear RNA is complexed with a major sextet of proteins in vivo.

1983 • 85 citations

Secondary structure of heterogeneous nuclear RNA: Two classes of double-stranded RNA in native ribonucleoprotein

1977 • 56 citations

Nucleoprotein organization of inverted repeat DNA transcripts in heterogeneous nuclear RNA-ribonucleoprotein particles from HeLa cells

1978 • 49 citations

Mammalian single-stranded DNA binding proteins and heterogeneous nuclear RNA proteins have common antigenic determinants

1985 • 48 citations

Influence of template primary and secondary structure on the rate and fidelity of DNA synthesis.

1985 • 48 citations

Appearance of rapidly labeled, high molecular weight RNA in nuclear ribonucleoprotein. Release from chromatin and association with protein.

1976 • 41 citations

Structure of complexes between a major protein of heterogeneous nuclear ribonucleoprotein particles and polyribonucleotides

1983 • 37 citations

Rapid preparation of bacteriophage DNA for sequence analysis in sets of 96 clones, using filtration

1986 • 33 citations

M13 vectors with 17 polymerase promoters: transcription limited by oligonodeotides

1986 • 20 citations

The dependence of splicing efficiency on the length of 3' exon

1988 • 20 citations

Nucleic acid binding properties of major proteins from the heterogeneous nuclear ribonucteoproteins of wheat

1982 • 10 citations

A model for the mechanism and control of eukaryote gene splicing

1982 • 9 citations