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The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

Data up to Jan 2025

Published2000
Citations195
References56

Total Citations Per Year

Abstract

References (56)

Receptor Specificity of the Fibroblast Growth Factor Family

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RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2α to the Assembly of Mammalian Stress Granules

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Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

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Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.

1989 • 349 citations

Identification of TIAR as a Protein Binding to the Translational Regulatory AU-rich Element of Tumor Necrosis Factor α mRNA

1999 • 256 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site.

1996 • 235 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers

1999 • 223 citations

Individual RNA Recognition Motifs of TIA-1 and TIAR Have Different RNA Binding Specificities

1996 • 223 citations

hnRNP A1 Recruited to an Exon In Vivo Can Function as an Exon Splicing Silencer

1999 • 219 citations

Post-transcriptional regulation: The dawn of PTB

1997 • 202 citations

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.

1996 • 200 citations

RNA-binding protein TIAR is essential for primordial germ cell development

1998 • 196 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

Identification and functional characterization of a TIA-1-related nucleolysin.

1992 • 183 citations

Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

1995 • 174 citations

Effects of SV40 transformation on the cytoskeleton and behavioural properties of human keratinocytes

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The determinants of RNA-binding specificity of the heterogeneous nuclear ribonucleoprotein C proteins.

1994 • 155 citations

Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.

1994 • 155 citations

A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.

1998 • 154 citations

Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element.

1994 • 150 citations

A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs.

1992 • 150 citations

Alternative Splicing and Programmed Cell Death

1999 • 133 citations

The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death.

1995 • 126 citations

The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta -tropomyosin alternative exon 6A

1997 • 124 citations

Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection

1999 • 123 citations

Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.

1996 • 115 citations

Exon and Intron Sequences, Respectively, Repress and Activate Splicing of a Fibroblast Growth Factor Receptor 2 Alternative Exon

1995 • 113 citations

Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition

1999 • 113 citations

Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex

1999 • 112 citations

UBP1, a novel hnRNP-like protein that functions at multiple steps of higher plant nuclear pre-mRNA maturation

2000 • 110 citations

An Intronic Sequence Element Mediates Both Activation and Repression of Rat Fibroblast Growth Factor Receptor 2 Pre-mRNA Splicing

1998 • 108 citations

Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR

1996 • 96 citations

Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA.

1993 • 93 citations

Multiple Interdependent Sequence Elements Control Splicing of a Fibroblast Growth Factor Receptor 2 Alternative Exon

1997 • 86 citations

Genetic and Physical Interactions Involving the Yeast Nuclear Cap-Binding Complex

1999 • 84 citations

Identification of a Bidirectional Splicing Enhancer: Differential Involvement of SR Proteins in 5′ or 3′ Splice Site Activation

1999 • 78 citations

Alternative splicing of E1A transcripts of adenovirus requires appropriate ionic conditions in vitro

1987 • 77 citations

The complex CD44 transcriptional unit: Alternative splicing of three internal exons generates the epithelial form of CD44

1992 • 75 citations

Combinatorial control of a neuron-specific exon

1999 • 71 citations

A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

1990 • 69 citations

The exon sequence TAGG can inhibit splicing

1996 • 66 citations

A New Alternatively Spliced Exon between v9 and v10 Provides a Molecular Basis for Synthesis of Soluble CD44

1996 • 59 citations

Involvement of the MRE2 gene of yeast in formation of meiosis‐specific double‐strand breaks and crossover recombination through RNA splicing

1997 • 44 citations

Intronic sequence with both negative and positive effects on the regulation of alternative transcripts of the chicken β trophmyosin transcripts

1992 • 41 citations

A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells

1992 • 15 citations

Expression of the CTL-associated protein TIA-1 during murine embryogenesis.

1996 • 12 citations

Deleted Work

1955 • 0 citations

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