The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Prediction of human mRNA donor and acceptor sites from the DNA sequence

1991 • 798 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

[16] Splice junctions, branch point sites, and exons: Sequence statistics, identification, and applications to genome project

1990 • 689 citations

Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region

1988 • 617 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.

1985 • 305 citations

Exon Definition May Facilitate Splice Site Selection in RNAs with Multiple Exons

1990 • 269 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Structure and function of major and minor small nuclear ribonucleoprotein particles

1989 • 242 citations

Rapid, small-scale RNA isolation from tissue culture cells.

1991 • 216 citations

The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family

1982 • 183 citations

Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.

1990 • 169 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene

1992 • 150 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

Exon skipping during splicing of dystrophin mRNA precursor due to an intraexon deletion in the dystrophin gene of Duchenne muscular dystrophy kobe.

1991 • 147 citations

Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

1991 • 146 citations

Nonsense Mutations in the Dihydrofolate Reductase Gene Affect RNA Processing

1989 • 139 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

A base substitution in the exon of a collagen gene causes alternative splicing and generates a structurally abnormal polypeptide in a patient with Ehlers-Danlos syndrome type VII.

1989 • 117 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

The role of branchpoint and 3'-exon sequences in the control of balanced splicing of avian retrovirus RNA.

1991 • 112 citations

Analysis of the upstream regions governing expression of the chicken cardiac troponin T gene in embryonic cardiac and skeletal muscle cells.

1988 • 109 citations

Exon mutations that affect the choice of splice sites used in processing the SV40 late transcripts

1985 • 103 citations

Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing

1989 • 101 citations

A novel exon mutation in the human beta-hexosaminidase beta subunit gene affects 3' splice site selection.

1992 • 98 citations

Selection of Splice Sites in Pre-mRNAs with Short Internal Exons

1991 • 89 citations

A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.

1992 • 89 citations

Hierarchy for 5′ splice site preference determined in vivo

1990 • 87 citations

A single nucleotide polymorphism in an exon dictates allele dependent differential splicing of episialin mRNA

1991 • 85 citations

Effect of 5′ Splice Site Mutations on Splicing of the Preceding Intron

1990 • 83 citations

Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells

1992 • 82 citations

Control of Retroviral RNA Splicing through Maintenance of Suboptimal Processing Signals

1990 • 75 citations

A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

1990 • 69 citations

The chicken fast skeletal troponin I gene: exon organization and sequence

1986 • 69 citations

Alternative Splicing In The Control Of Gene Expression

1989 • 66 citations

Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP

1992 • 64 citations

Translation to Near the Distal End of the Penultimate Exon Is Required for Normal Levels of Spliced Triosephosphate Isomerase mRNA

1990 • 55 citations

In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron.

1992 • 51 citations

Identification of a cis-acting sequence required for germ line-specific splicing of the P element ORF2-ORF3 intron.

1991 • 47 citations

Molecular analysis of hprt mutants induced by 2-cyanoethylene oxide in human lymphoblastoid cells

1990 • 41 citations

Cooperation of pre-mRNA sequence elements in splice site selection.

1992 • 40 citations

The conserved dinucleotide AG of the 3′ splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors

1990 • 31 citations

Identification of a Specific Exon Sequence That Is a Major Determinant in the Selection between a Natural and a Cryptic 5′ Splice Site

1991 • 21 citations

Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites.

1990 • 21 citations

Exon recognition and nucleocytoplasmic partitioning determine AMPD1 alternative transcript production.

1991 • 18 citations

Spontaneous Splicing Mutations at the Dihydrofolate Reductase Locus in Chinese Hamster Ovary Cells

1986 • 16 citations

Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA.

1989 • 12 citations