A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

The Yeast Nuclear Pore Complex

2000 • 1,383 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Integrating mRNA Processing with Transcription

2002 • 1,054 citations

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

2000 • 923 citations

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

2001 • 799 citations

Transport of Proteins and RNAs in and out of the Nucleus

1999 • 741 citations

Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon

2000 • 571 citations

RNA polymerase II and the integration of nuclear events

2000 • 561 citations

TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus

1998 • 557 citations

A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

1999 • 524 citations

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

2000 • 514 citations

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores

1997 • 510 citations

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

1998 • 476 citations

Structural Basis for the Interaction between FxFG Nucleoporin Repeats and Importin-β in Nuclear Trafficking

2000 • 440 citations

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

1999 • 431 citations

Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

2001 • 385 citations

Splicing Factors SRp20 and 9G8 Promote the Nucleocytoplasmic Export of mRNA

2001 • 377 citations

Communication of the Position of Exon-Exon Junctions to the mRNA Surveillance Machinery by the Protein RNPS1

2001 • 376 citations

Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

2000 • 375 citations

Splicing is required for rapid and efficient mRNA export in metazoans

1999 • 375 citations

PHAX, a Mediator of U snRNA Nuclear Export Whose Activity Is Regulated by Phosphorylation

2000 • 371 citations

REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export

2000 • 365 citations

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export

2000 • 351 citations

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

2000 • 329 citations

Pre-mRNA Splicing Imprints mRNA in the Nucleus with a Novel RNA-Binding Protein that Persists in the Cytoplasm

2000 • 326 citations

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p

2001 • 314 citations

A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export.

1996 • 298 citations

Role of the Nonsense-Mediated Decay Factor hUpf3 in the Splicing-Dependent Exon-Exon Junction Complex

2001 • 292 citations

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

1997 • 286 citations

Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

1999 • 283 citations

U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.

1997 • 277 citations

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export

1998 • 272 citations

Nucleocytoplasmic transport enters the atomic age

2001 • 270 citations

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export

1998 • 267 citations

Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides

2001 • 266 citations

Nuclear mRNA Export Requires Complex Formation between Mex67p and Mtr2p at the Nuclear Pores

1998 • 263 citations

Nuclear pores and nuclear assembly

2001 • 251 citations

A Role for the M9 Transport Signal of hnRNP A1 in mRNA Nuclear Export

1997 • 249 citations

REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus

2001 • 248 citations

The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

1999 • 246 citations

Transport routes through the nuclear pore complex

1998 • 240 citations

Structural Basis for the Recognition of a Nucleoporin FG Repeat by the NTF2-like Domain of the TAP/p15 mRNA Nuclear Export Factor

2001 • 233 citations

An RNA-export mediator with an essential nuclear export signal

1996 • 230 citations

Binding of the Mex67p/Mtr2p Heterodimer to Fxfg, Glfg, and Fg Repeat Nucleoporins Is Essential for Nuclear mRNA Export

2000 • 229 citations

Coupling RNA polymerase II transcription with pre-mRNA processing

1999 • 228 citations

Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast

1997 • 225 citations

The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila

2001 • 224 citations

TAP (NXF1) Belongs to a Multigene Family of Putative RNA Export Factors with a Conserved Modular Architecture

2000 • 224 citations

Messenger RNAs are recruited for nuclear export during transcription

2001 • 220 citations

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells

1999 • 209 citations

Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPase

2001 • 205 citations

A Block to mRNA Nuclear Export in S. cerevisiae Leads to Hyperadenylation of Transcripts that Accumulate at the Site of Transcription

2001 • 194 citations

Proteomic Analysis of Nucleoporin Interacting Proteins

2001 • 188 citations

Pre-mRNA processing factors are required for nuclear export

2000 • 185 citations

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

2001 • 180 citations

GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function.

1996 • 168 citations

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr255p

1999 • 155 citations

Distinct RNP Complexes of Shuttling hnRNP Proteins with Pre-mRNA and mRNA: Candidate Intermediates in Formation and Export of mRNA

2001 • 152 citations

The Yeast hnRNP-Like Proteins Yra1p and Yra2p Participate in mRNA Export through Interaction with Mex67p

2001 • 151 citations

The DECD box putative ATPase Sub2p is an early mRNA export factor

2001 • 151 citations

A Look at Messenger RNP Moving through the Nuclear Pore

1997 • 149 citations

Conserved Sr Protein Kinase Functions in Nuclear Import and Its Action Is Counteracted by Arginine Methylation inSaccharomyces cerevisiae

2000 • 149 citations

A Mutation in the Schizosaccharomyces pombe rae1 Gene Causes Defects in Poly(A)+ RNA Export and in the Cytoskeleton

1995 • 149 citations

Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing

1999 • 146 citations

The 1.6 Å Resolution Crystal Structure of Nuclear Transport Factor 2 (NTF2)

1996 • 145 citations

Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation

2001 • 141 citations

Overexpression of TAP/p15 Heterodimers Bypasses Nuclear Retention and Stimulates Nuclear mRNA Export

2001 • 135 citations

Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA

1998 • 127 citations

Identification of Novel Import and Export Signals of Human TAP, the Protein That Binds to the Constitutive Transport Element of the Type D Retrovirus mRNAs

1999 • 125 citations

Multiple roles for the yeast SUB2/yUAP56 gene in splicing

2001 • 118 citations

Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56

2001 • 116 citations

Two Closely Related Human Nuclear Export Factors Utilize Entirely Distinct Export Pathways

2001 • 112 citations

Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import

2001 • 110 citations

NXT1 (p15) Is a Crucial Cellular Cofactor in TAP-Dependent Export of Intron-Containing RNA in Mammalian Cells

2001 • 106 citations

The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p

2000 • 106 citations

Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export

2001 • 94 citations

mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm

1997 • 88 citations

The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A) ⁺ RNA export

1998 • 84 citations

Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts

2001 • 84 citations

Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant.

1994 • 79 citations

A Human Nuclear-Localized Chaperone that Regulates Dimerization, DNA Binding, and Transcriptional Activity of bZIP Proteins

1999 • 77 citations

Nascent Ribosomes

2001 • 77 citations

A new view of mRNA export: Separating the wheat from the chaff

2001 • 75 citations

A Ran-independent pathway for export of spliced mRNA

2000 • 75 citations

Mex67p of Schizosaccharomyces pombe Interacts with Rae1p in Mediating mRNA Export

2000 • 67 citations

7The Yeast mRNA-binding Protein Npl3p Interacts with the Cap-binding Complex

2000 • 66 citations

Two yeast nuclear pore complex proteins involved in mRNA export form a cytoplasmically oriented subcomplex

1998 • 59 citations

YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity.

1997 • 56 citations

The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family

1995 • 55 citations

In Vitro Analysis of Nuclear Transport Mediated by the C-terminal Shuttle Domain of Tap

2001 • 34 citations

Splicing-Independent Expression of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene Is Mediated by Three cis -Acting RNA Subelements

1998 • 20 citations