Regulation of SR protein localization during development

Sorting out the complexity of SR protein functions

2000 • 1,064 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

RNA polymerase II and the integration of nuclear events

2000 • 561 citations

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

1996 • 559 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

1998 • 476 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

1997 • 394 citations

Splicing Factors SRp20 and 9G8 Promote the Nucleocytoplasmic Export of mRNA

2001 • 377 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

1994 • 325 citations

Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4

1999 • 324 citations

RNA Polymerase II Targets Pre-mRNA Splicing Factors to Transcription Sites In Vivo

1999 • 322 citations

Regulation of Gene Expression at the Beginning of Mammalian Development

1995 • 290 citations

Serine Phosphorylation of SR Proteins Is Required for Their Recruitment to Sites of Transcription In Vivo

1998 • 277 citations

Splicing Factors Associate with Hyperphosphorylated RNA Polymerase II in the Absence of Pre-mRNA

1997 • 245 citations

Transportin-SR, a Nuclear Import Receptor for SR Proteins

1999 • 244 citations

The cellular organization of gene expression

1998 • 243 citations

Phosphorylated RNA polymerase II stimulates pre-mRNA splicing

1999 • 239 citations

The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing

1999 • 223 citations

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2

1998 • 200 citations

Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.

1994 • 199 citations

A Human Importin-β Family Protein, Transportin-SR2, Interacts with the Phosphorylated RS Domain of SR Proteins

2000 • 198 citations

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.

1997 • 192 citations

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer

1997 • 192 citations

SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

1995 • 167 citations

Conserved Sr Protein Kinase Functions in Nuclear Import and Its Action Is Counteracted by Arginine Methylation inSaccharomyces cerevisiae

2000 • 149 citations

Phosphorylation Regulates In Vivo Interaction and Molecular Targeting of Serine/Arginine-rich Pre-mRNA Splicing Factors

1999 • 146 citations

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription.

1997 • 141 citations

Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation

2001 • 141 citations

The Subcellular Localization of SF2/ASF Is Regulated by Direct Interaction with SR Protein Kinases (SRPKs)

1999 • 136 citations

Conservation in budding yeast of a kinase specific for SR splicing factors

1999 • 125 citations

Targeting of U2AF65 to Sites of Active Splicing in the Nucleus

1997 • 124 citations

Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos

1997 • 102 citations

Stability of Maternal mRNA in Xenopus Embryos: Role of Transcription and Translation

1990 • 65 citations

Developmental regulation of SR protein phosphorylation and activity

1999 • 61 citations

Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters.

1989 • 60 citations

The small nuclear RNAs for pre-mRNA splicing are coordinately regulated during oocyte maturation and early embryogenesis in the mouse

1989 • 49 citations

Serine–arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing

1999 • 47 citations

Extremely Stable Transcripts May Compensate for the Elimination of the Gene fert-1 from All Ascaris lumbricoides Somatic Cells

1994 • 42 citations

Localization and expression of U1 RNA in early mouse embryo development

1988 • 40 citations

U2 small nuclear RNA localization and expression during bovine preimplantation development

1992 • 28 citations

SR proteins are required for nematode trans-splicing in vitro

1999 • 22 citations

Transcription in nematodes: Early Ascaris embryos are transcriptionally active

1989 • 20 citations

Relocalization of small ribonucleoprotein particles (snRNPs) during the first cell cycle of mouse embryo development is independent of RNA synthesis, DNA synthesis and cytokinesis

1990 • 12 citations

A novel UV-damaged DNA binding protein emerges during the chromatin- eliminating cleavage period in Ascaris suum

1998 • 10 citations