Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

1994 • 827 citations

hnRNP complexes: composition, structure, and function

1999 • 794 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

SR proteins and splicing control.

1996 • 668 citations

ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

1998 • 644 citations

Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

1995 • 537 citations

Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability

2000 • 415 citations

Purified lupus antigen la recognizes an oligouridylate stretch common to the 3′ termini of RNA polymerase III transcripts

1984 • 382 citations

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

1999 • 370 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

1998 • 334 citations

Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.

1988 • 327 citations

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

1997 • 324 citations

Sequence-Specific RNA Binding by a Nova KH Domain

2000 • 323 citations

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

1994 • 315 citations

Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

1993 • 313 citations

RNA RECOGNITION BY RNP PROTEINS DURING RNA PROCESSING

1998 • 299 citations

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

1992 • 299 citations

RNA-binding proteins as regulators of gene expression

1997 • 263 citations

The SR protein family: pleiotropic functions in pre-mRNA splicing

1996 • 259 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing

1999 • 253 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

hnRNP H Is a Component of a Splicing Enhancer Complex That Activates a c-srcAlternative Exon in Neuronal Cells

1999 • 247 citations

Specificity of ribonucleoprotein interaction determined by RNA folding during complex formation

1996 • 245 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.

1997 • 233 citations

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing

2000 • 231 citations

The Polypyrimidine Tract Binding Protein Binds Upstream of Neural Cell-Specific c-src Exon N1 To Repress the Splicing of the Intron Downstream

1997 • 214 citations

A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart.

1997 • 213 citations

Trans splicing of mRNA precursors

1985 • 205 citations

Post-transcriptional regulation: The dawn of PTB

1997 • 202 citations

Transcription Processivity: Protein-DNA Interactions Holding Together the Elongation Complex

1996 • 197 citations

Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta -tropomyosin gene

1999 • 195 citations

The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event.

1995 • 194 citations

Multisite RNA Binding and Release of Polypyrimidine Tract Binding Protein during the Regulation of c-src Neural-Specific Splicing

2000 • 193 citations

Directing alternative splicing: cast and scenarios

1996 • 187 citations

The Far Upstream Element-binding Proteins Comprise an Ancient Family of Single-strand DNA-binding Transactivators

1996 • 178 citations

Cell Type-Specific Expression of hnRNP Proteins

1995 • 177 citations

Nucleolin is a Sequence-specific RNA-binding Protein: Characterization of Targets on Pre-ribosomal RNA

1996 • 177 citations

Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

1992 • 171 citations

Regulation of alternative 3' splice site selection by constitutive splicing factors.

1995 • 170 citations

Multiple RRMs Contribute to RNA Binding Specificity and Affinity for Polypyrimidine Tract Binding Protein

1997 • 168 citations

Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.

1992 • 157 citations

Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element.

1994 • 150 citations

Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression

2000 • 148 citations

The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization

1994 • 147 citations

Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

1992 • 142 citations

ASESORÍAS INNOVADORAS EN RECURSOS HUMANOS PARA LAS PYMES MEDIANTE EL USO DE LA RED DE INTERNET

1969 • 136 citations

A Complex Intronic Splicing Enhancer from the c-src Pre-mRNA Activates Inclusion of a Heterologous Exon

1997 • 133 citations

Splicing Regulation in Neurons: Tinkering with Cell-Specific Control

1998 • 129 citations

An Intron Element Modulating 5′ Splice Site Selection in the hnRNP A1 Pre-mRNA Interacts with hnRNP A1

1997 • 123 citations

5′ Processing of tRNA Precursors Can Be Modulated by the Human La Antigen Phosphoprotein

1998 • 118 citations

An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken β-tropomyosin pre-mRNA

1995 • 116 citations

Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB

1999 • 116 citations

Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro

1997 • 111 citations

Regulation of pre-mRNA splicing in metazoa

1997 • 110 citations

Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator

1999 • 107 citations

Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs

1997 • 105 citations

Alternative Splicing of the Fibronectin EIIIB Exon Depends on Specific TGCATG Repeats

1998 • 105 citations

An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon.

1996 • 95 citations

Protein-RNA interactions in the active center of transcription elongation complex.

1996 • 90 citations

Determination of functional domains in polypyrimidine-tract-binding protein

1998 • 90 citations

The Function of Multisite Splicing Enhancers

1998 • 81 citations

Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro

1995 • 81 citations

Polypyrimidine tract‐binding protein interacts with HnRNP L

1998 • 77 citations

Immunocytochemical localization of the neuron-specific form of the c- src gene product, pp60c-src(+), in rat brain

1990 • 76 citations

Neuron-specific Alternative Splicing of Nonmuscle Myosin II Heavy Chain-B Pre-mRNA Requires a Cis-acting Intron Sequence

1996 • 72 citations

Combinatorial control of a neuron-specific exon

1999 • 71 citations

The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points

1998 • 70 citations

A Unique Transactivation Sequence Motif Is Found in the Carboxyl-Terminal Domain of the Single-Strand-Binding Protein FBP

1996 • 70 citations

Control of 3' splice site choice in vivo by ASF/SF2 and hnRNP A1

1999 • 69 citations

Elements regulating an alternatively spliced exon of the rat fibronectin gene.

1993 • 62 citations

Control of alternative pre-mRNA splicing by distributed pentameric repeats

1997 • 53 citations

Mammalian pre-mRNA splicing factors

1997 • 53 citations

Oligonucleotide binding specificities of the hnRNP C protein tetramer

1998 • 19 citations

Alternative pre-mRNA splicing

1997 • 19 citations

Tissue-specific splicing of two mutually exclusive exons of the chicken β-tropomyosin pre-mRNA: Positive and negative regulations

1996 • 11 citations

The packaging of pre-Mrna

1997 • 6 citations