SR proteins: a conserved family of pre-mRNA splicing factors.

Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes

1980 • 1,256 citations

Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose.

1987 • 819 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

RNA recognition: towards identifying determinants of specificity

1991 • 739 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation

1988 • 401 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.

1991 • 255 citations

Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. laevis

1991 • 248 citations

Isolation of a Complementary DNA that Encodes the Mammalian Splicing Factor SC35

1992 • 244 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing

1991 • 224 citations

A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.

1990 • 193 citations

[7] Finding protein similarities with nucleotide sequence databases

1990 • 192 citations

RNP particles at splice junction sequences on Drosophila chorion transcripts

1985 • 191 citations

Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes.

1991 • 182 citations

Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus

1991 • 159 citations

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins

1989 • 156 citations

Regulated Splicing of the Drosophila P Transposable Element Third Intron in Vitro: Somatic Repression

1990 • 149 citations

Developmental expression of a regulatory gene is programmed at the level of splicing.

1987 • 143 citations

UsnRNP Assembly and Transport

1988 • 142 citations

Intranuclear localization of snRNP antigens.

1986 • 140 citations

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

Redistribution of U-snRNPs during mitosis

1986 • 108 citations

Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin.

1991 • 104 citations

Spliced leader RNA sequences can substitute for the essential 5′ end of U1 RNA during splicing in a mammalian in vitro system

1990 • 92 citations

5′-terminal caps of snRNAs are reactive with antibodies specific for 2,2,7-trimethylguanosine in whole cells and nuclear matrices

1984 • 79 citations

A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs

1991 • 77 citations

Accurate and efficient pre-mRNA splicing in Drosophila cell-free extracts.

1988 • 69 citations

PATMAT: a searching and extraction program for sequence, pattern and block queries and databases

1992 • 64 citations

Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters.

1989 • 60 citations

C-myb proto-oncogene: evidence for intermolecular recombination of coding sequences.

1991 • 25 citations

Playing with blocks: some pitfalls of forcing multiple alignments.

1991 • 23 citations

Intermolecular recombination of the c-myb proto-oncogene coding sequences in chicken: clues for a mechanism.

1990 • 6 citations

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