Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins.

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

1993 • 663 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing.

1994 • 481 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Identification and characterization of the packaging proteins of core 40S hnRNP particles

1977 • 451 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Heterogeneous Nuclear Ribonucleoproteins: Role in RNA Splicing

1986 • 399 citations

Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.

1988 • 399 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

1992 • 299 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.

1992 • 273 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing

1994 • 261 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.

1993 • 243 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site

1983 • 237 citations

Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.

1989 • 236 citations

Nuclear Proteins That Bind the Pre-mRNA 3' Splice Site Sequence r(UUAG/G) and the Human Telomeric DNA Sequence d(TTAGGG)_n

1993 • 236 citations

Protein components specifically associated with prespliceosome and spliceosome complexes.

1992 • 218 citations

Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences.

1993 • 208 citations

RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

1991 • 196 citations

Functional domains of the human splicing factor ASF/SF2.

1993 • 188 citations

Interaction of the RNA-binding domain of the hnRNP C proteins with RNA.

1992 • 186 citations

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

1994 • 186 citations

Phenylalanines that are conserved among several RNA-binding proteins form part of a nucleic acid-binding pocket in the A1 heterogeneous nuclear ribonucleoprotein.

1988 • 180 citations

Close encounters: why unstructured, polymeric domains can increase rates of specific macromolecular association

1993 • 177 citations

Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. Large-scale overproduction in Escherichia coli and cooperative binding to single-stranded nucleic acids.

1988 • 170 citations

Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.

1992 • 157 citations

RNA annealing activities in HeLa nuclei.

1994 • 148 citations

Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

1992 • 142 citations

Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

1990 • 139 citations

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGG_n

1992 • 129 citations

Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins.

1986 • 123 citations

Antibodies to hnRNP core proteins inhibitin vitrosplicing of human β-globin pre-mRNA

1986 • 119 citations

Studies of the strand-annealing activity of mammalian hnRNP complex protein A1

1990 • 114 citations

Nucleic acid helix-coil transitions mediated by helix-unwinding proteins from calf thymus.

1976 • 109 citations

cDNA cloning of human hnRNP protein Al reveals the existence of multiple mRNA isoforms

1988 • 107 citations

Human SR Proteins and Isolation of a cDNA Encoding SRp75

1993 • 105 citations

Heterogeneous nuclear ribonucleoprotein A1 catalyzes RNA.RNA annealing.

1992 • 98 citations

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2.

1992 • 90 citations

Antisense RNA inhibits splicing of pre-mRNA in vitro.

1988 • 89 citations

Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

1990 • 86 citations

Amino acid sequence of the UP1 calf thymus helix-destabilizing protein and its homology to an analogous protein from mouse myeloma.

1985 • 82 citations

Retroviral Insertions Downstream of the Heterogeneous Nuclear Ribonucleoprotein Al Gene in Erythroleukemia Cells: Evidence that Al Is Not Essential for Cell Growth

1992 • 79 citations

Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: Evidence for multiple RNA binding domains and salt-dependent binding mode transitions

1991 • 78 citations

Isolation of an active gene encoding human hnRNP protein A1

1989 • 77 citations

Modulation of Exon Skipping and Inclusion by Heterogeneous Nuclear Ribonucleoprotein A1 and Pre-mRNA Splicing Factor SF2/ASF

1993 • 76 citations

The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.

1994 • 72 citations

Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1

1994 • 59 citations

RNA annealing activity is intrinsically associated with U2AF

1993 • 59 citations

Rapid assembly and disassembly of complementary DNA strands through an equilibrium intermediate state mediated by A1 hnRNP protein.

1992 • 57 citations

Essential role for a heterogeneous nuclear ribonucleoprotein (hnRNP) in oogenesis: hrp40 is absent from the germ line in the dorsoventral mutant squid.

1994 • 57 citations

Crosslinking of hnRNP protiens to pre-mRNA requires U1 and U2 snRNPs

1990 • 54 citations

Mammalian heterogeneous nuclear ribonucleoprotein A1. Nucleic acid binding properties of the COOH-terminal domain.

1990 • 53 citations

Mammalian Heterogeneous Ribonucleoprotein A1 and its Constituent Domains

1993 • 52 citations

Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly

1992 • 49 citations

TheRb97Dgene encodes a potential RNA-binding protein required for spermatogenesis inDrosophila

1993 • 47 citations

A novel protein factor is required for use of distal alternative 5' splice sites in vitro.

1991 • 42 citations

Determination of the Secondary Structure and Folding Topology of an RNA Binding Domain of Mammalian hnRNP A1 Protein Using Three-Dimensional Heteronuclear Magnetic Resonance Spectroscopy

1994 • 38 citations

Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro.

1988 • 36 citations

Purification and RNA binding properties of a C-type hnRNP protein from HeLa cells.

1987 • 33 citations

The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles

1994 • 32 citations

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA

1986 • 32 citations

A Novel Protein Factor Is Required for Use of Distal Alternative 5' Splice Sites In Vitro

1991 • 22 citations

Identification of nuclear proteins that specifically bind to RNAs containing 5' splice sites.

1991 • 19 citations

β-globin transcripts carrying a single intron with three adjacent nucleotides of 5′ exon are efficiently splicedin vitroirrespective of intron position or surrounding exon sequences

1990 • 17 citations

Physical studies of tyrosine and tryptophan residues in mammalian A1 heterogeneous nuclear ribonucleoprotein Support for a segmented structure

1991 • 17 citations

Short Donor Site Sequences Inserted within the Intron of β-Globin Pre-mRNA Serve for Splicing In Vitro

1988 • 16 citations