SR proteins and splicing control.

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

1993 • 663 citations

Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

1994 • 622 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Cloning and domain structure of the mammalian splicing factor U2AF

1992 • 566 citations

Split genes and RNA splicing

1994 • 562 citations

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

1996 • 559 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

Sex in flies: the splice of life

1989 • 468 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

DYNAMIC RNA-RNA INTERACTIONS IN THE SPLICEOSOME

1994 • 356 citations

The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.

1995 • 351 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

1994 • 325 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

1996 • 286 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.

1995 • 282 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA

1996 • 258 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Isolation of a Complementary DNA that Encodes the Mammalian Splicing Factor SC35

1992 • 244 citations

Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.

1993 • 243 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

Polypurine sequences within a downstream exon function as a splicing enhancer.

1994 • 222 citations

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

1992 • 209 citations

Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit.

1992 • 203 citations

Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.

1994 • 199 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.

1992 • 198 citations

A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.

1990 • 193 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.

1991 • 192 citations

Functional domains of the human splicing factor ASF/SF2.

1993 • 188 citations

The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2

1994 • 182 citations

A Subset of SR Proteins Activates Splicing of the Cardiac Troponin T Alternative Exon by Direct Interactions with an Exonic Enhancer

1995 • 180 citations

Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.

1995 • 174 citations

Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing.

1992 • 168 citations

SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

1995 • 167 citations

SR proteins can compensate for the loss of U1 snRNP functions in vitro.

1994 • 160 citations

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins

1989 • 156 citations

Synergistic interactions between two distinct elements of a regulated splicing enhancer.

1995 • 156 citations

Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.

1994 • 155 citations

Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing

1993 • 152 citations

Complementation by SR Proteins of Pre-mRNA Splicing Reactions Depleted of U1 snRNP

1994 • 152 citations

Developmental expression of a regulatory gene is programmed at the level of splicing.

1987 • 143 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

1995 • 133 citations

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

1991 • 128 citations

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

1993 • 124 citations

Factors influencing alternative splice site utilization in vivo.

1987 • 120 citations

The SR protein B52/SRp55 is essential for Drosophila development.

1994 • 112 citations

U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: characterization of required elements

1995 • 111 citations

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites.

1994 • 107 citations

Human SR Proteins and Isolation of a cDNA Encoding SRp75

1993 • 105 citations

Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin.

1991 • 104 citations

Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing

1993 • 104 citations

Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5' splice sites.

1995 • 102 citations

The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences.

1995 • 100 citations

Characterization by cDNA Cloning of Two New Human Protein Kinases

1994 • 98 citations

A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA.

1994 • 95 citations

A 32-Nucleotide Exon-Splicing Enhancer Regulates Usage of Competing 5′ Splice Sites in a Differential Internal Exon

1995 • 93 citations

Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors

1993 • 92 citations

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2.

1992 • 90 citations

Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF.

1995 • 89 citations

A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon.

1992 • 89 citations

Splicing of pre-mRNA: mechanism, regulation and role in development

1993 • 86 citations

Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps.

1995 • 86 citations

A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs

1991 • 77 citations

Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements.

1993 • 68 citations

SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element

1996 • 62 citations

A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing.

1995 • 60 citations

Genetic Enhancement of RNA-Processing Defects by a Dominant Mutation in B52, the Drosophila Gene for an SR Protein Splicing Factor

1995 • 42 citations