A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides

1989 • 685 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Cloning and domain structure of the mammalian splicing factor U2AF

1992 • 566 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Sex in flies: the splice of life

1989 • 468 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

SEX AND THE SINGLE CELL. I. ON THE ACTION OF MAJOR LOCI AFFECTING SEX DETERMINATION IN DROSOPHILA MELANOGASTER

1980 • 355 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

Control of doublesex Alternative Splicing by transformer and transformer-2 in Drosophila

1991 • 333 citations

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA

1993 • 309 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Isolation of a Complementary DNA that Encodes the Mammalian Splicing Factor SC35

1992 • 244 citations

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

1992 • 241 citations

Affinity Chromatography of Splicing Complexes: U2, U5, and U4 + U6 Small Nuclear Ribonucleoprotein Particles in the Spliceosome

1986 • 238 citations

Cloning of the human cDNA for the U1 RNA-associated 70K protein.

1986 • 235 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Protein components specifically associated with prespliceosome and spliceosome complexes.

1992 • 218 citations

Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

1991 • 200 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.

1992 • 198 citations

On/off regulation of gene expression at the level of splicing

1988 • 186 citations

Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation.

1991 • 184 citations

Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro

1992 • 171 citations

Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.

1990 • 169 citations

Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing.

1992 • 168 citations

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins

1989 • 156 citations

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

1992 • 154 citations

Regulated Splicing of the Drosophila P Transposable Element Third Intron in Vitro: Somatic Repression

1990 • 149 citations

Developmental expression of a regulatory gene is programmed at the level of splicing.

1987 • 143 citations

Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

1992 • 142 citations

Are vertebrate exons scanned during splice-site selection?

1992 • 141 citations

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

1992 • 131 citations

Purification and visualization of native spliceosomes

1988 • 121 citations

Presplicing complex formation requires two proteins and U2 snRNP.

1988 • 117 citations

Genetic Control Of Sex Determination In Drosophila

1990 • 114 citations

Protein composition of mammalian spliceosomes assembled in vitro.

1990 • 112 citations

The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2.

1992 • 90 citations

Purification of RNA and RNA-protein complexes by an R17 coat protein affinity method

1990 • 82 citations

Identification of a functional mammalian spliceosome containing unspliced pre-mRNA.

1988 • 75 citations

Structure and Expression of the Drosophila melanogaster Gene for the U1 Small Nuclear Ribonucleoprotein Particle 70K Protein

1990 • 70 citations

A specific, UV-induced RNA-protein crosslink using 5-bromouridine-substituted RNA

1991 • 58 citations

Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro.

1992 • 56 citations

Genetic and developmental analysis of the sex-determining gene ‘double sex’ (dsx) ofDrosophila melanogaster

1987 • 42 citations

Alternative splicing is an efficient mechanism for the generation of protein diversity: Contractile protein genes as a model system

1991 • 40 citations

Structure and expression of the Drosophila melanogaster gene for the U1 small nuclear ribonucleoprotein particle 70K protein.

1990 • 35 citations

RNA binding proteins, splice site selection, and alternative pre-mRNA splicing.

1992 • 30 citations