Increase of reactive oxygen species (ROS) in endothelial cells by shear flow and involvement of ROS in shear-induced c-fos expression

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

1992 • 2,536 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 • 1,808 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

1993 • 1,126 citations

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

1986 • 1,106 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

1996 • 851 citations

The Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress

1985 • 699 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

1994 • 637 citations

Nitric oxide and oxygen radicals: a question of balance

1995 • 568 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.

1994 • 389 citations

Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes

1996 • 351 citations

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.

1994 • 349 citations

Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells

1996 • 294 citations

Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells

1995 • 287 citations

Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress

1990 • 276 citations

Stimulation of Transcription Factors NFκB and AP1 in Endothelial Cells Subjected to Shear Stress

1994 • 271 citations

Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescin

1994 • 262 citations

Cyclic Strain–Induced Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells Involves Reactive Oxygen Species Activation of Activator Protein 1

1997 • 246 citations

MAP Kinase Activation by Flow in Endothelial Cells

1996 • 224 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.

1994 • 215 citations

Pulsatile and steady flow induces c‐fos expression in human endothelial cells

1993 • 203 citations

Structure-Function Relationship of Lipoprotein Lipase-mediated Enhancement of Very Low Density Lipoprotein Binding and Catabolism by the Low Density Lipoprotein Receptor

1996 • 153 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

Mechanical Strain Induces Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells

1995 • 122 citations

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells

1995 • 122 citations

Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression. Effect of Sulfhydryl Modifying Agents

1994 • 72 citations

Cyclic Strain-Induced Plasminogen Activator Inhibitor-1 (PAI-1) Release from Endothelial Cells Involves Reactive Oxygen Species

1996 • 68 citations

Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression

1994 • 63 citations

Role of catalase in metabolism of hydrogen peroxide by the perfused rat heart

1986 • 38 citations

Fluid shear stress induction of the transcriptional activator c-fos in human and bovine endothelial cells, HeLa, and Chinese hamster ovary cells

2000 • 34 citations

Oxidant-sensitive protein phosphorylation in endothelial cells

1994 • 33 citations