Direct Association with Thioredoxin Allows Redox Regulation of Glucocorticoid Receptor Function

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

THIOREDOXIN

1985 • 1,885 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Nuclear receptor coactivators

1997 • 720 citations

A new class of yeast transcriptional activators

1987 • 706 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Eukaryotic Transcription: An Interlaced Network of Transcription Factors and Chromatin-Modifying Machines

1998 • 561 citations

Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene

1996 • 529 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide

1995 • 430 citations

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

1995 • 425 citations

Ligand binding was acquired during evolution of nuclear receptors

1997 • 407 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells.

1995 • 240 citations

Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.

1995 • 240 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

Identification of a Novel RING Finger Protein as a Coregulator in Steroid Receptor-Mediated Gene Transcription

1998 • 210 citations

Physical and Functional Sensitivity of Zinc Finger Transcription Factors to Redox Change

1996 • 192 citations

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

1996 • 170 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

The Function of Steroid Hormone Receptors Is Inhibited by the hsp90-specific Compound Geldanamycin

1997 • 162 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1985 • 158 citations

DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein.

1993 • 146 citations

Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism

1992 • 138 citations

Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator

1997 • 133 citations

Cloning and Characterization of the Nucleoredoxin Gene That Encodes a Novel Nuclear Protein Related to Thioredoxin

1997 • 118 citations

Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway.

1996 • 113 citations

Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion.

1997 • 103 citations

Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells.

1996 • 100 citations

High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein

1991 • 99 citations

Functional Dissection of the α and β Subunits of Transcription Factor PEBP2 and the Redox Susceptibility of Its DNA Binding Activity

1996 • 97 citations

Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor

1991 • 90 citations

Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor.

1992 • 89 citations

Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax

1996 • 82 citations

Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.

1992 • 80 citations

Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

1992 • 77 citations

Sulfhydryl-modifying reagents reversibly inhibit binding of glucocorticoid-receptor complexes to DNA-cellulose

1984 • 71 citations

Immunocytochemical analysis of hormone mediated nuclear translocation of wild type and mutant glucocorticoid receptors

1995 • 67 citations

Role of ATL-derived factor (ADF) in the normal and abnormal cellular activation: Involvement of dithiol related reduction

1990 • 64 citations

Assembly of a glucocorticoid receptor complex prior to DNA binding enhances its specific interaction with a glucocorticoid response element

1991 • 58 citations

Oncogenic conversion of Ets affects redox regulationin-vivoandin-vitro

1993 • 54 citations

[39] Glucocorticoid receptor thiols andsteroid-binding activity

1995 • 46 citations

Modulation of glucocorticoid-inducible gene expression by metal ions.

1996 • 26 citations

Immunophilins, Heat Shock Proteins, and Glucocorticoid Receptor Actionsin Vivo

1996 • 18 citations

Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations.

1995 • 6 citations