Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection

1994 • 379 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.

1994 • 331 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Negative feedback regulation of wild-type p53 biosynthesis.

1995 • 281 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

1993 • 182 citations

Interaction of p53 with Its Consensus DNA-Binding Site

1995 • 146 citations

Hypoxia Induces Accumulation of p53 Protein, but Activation of a G₁-Phase Checkpoint by Low-Oxygen Conditions Is Independent of p53 Status

1994 • 144 citations

Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T antigen

1990 • 122 citations

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

1989 • 122 citations

Rapid "footprinting" on supercoiled DNA.

1985 • 121 citations

Rapid and Preferential Activation of the c-jun Gene during the Mammalian UV Response

1991 • 120 citations

Formation of stable p53 homotetramers and multiples of tetramers

1992 • 110 citations

Identification of a Novel p53 Promoter Element Involved in Genotoxic Stress-Inducible p53 Gene Expression

1995 • 106 citations

Apoptosis in Human Adenocarcinoma HT29 Cells Induced by Exposure to Hypoxia

1995 • 95 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

Activation of AP-1 and of a Nuclear Redox Factor, Ref-1, in the Response of HT29 Colon Cancer Cells to Hypoxia

1994 • 52 citations

p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner

1995 • 38 citations

Epitope analysis of the murine p53 tumour suppressor protein.

1996 • 32 citations