Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Oxidative stress: From basic research to clinical application

1991 • 1,302 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Structure and function of glutathione S-transferases

1994 • 638 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

1990 • 472 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Free radical formation by antitumor quinones

1989 • 419 citations

A methodology for analysis of tissue sulfhydryl components

1972 • 413 citations

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

1994 • 303 citations

Glutathione S-Transferases: Gene Structure and Regulation of Expression

1993 • 300 citations

Ionizing radiation regulates expression of the c-jun protooncogene.

1990 • 297 citations

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper

1995 • 280 citations

Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells

1994 • 263 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

1992 • 230 citations

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

1995 • 222 citations

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1992 • 212 citations

[9] Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo

1990 • 195 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

1992 • 179 citations

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1994 • 152 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

Decrease in mouse lung and liver glutathione peroxidase activity and potentiation of the lethal effects of ozone and paraquat by the superoxide dismutase inhibitor diethyldithio-carbamate

1979 • 97 citations

Quantitative determination of SH groups in low- and high-molecular-weight compounds by an electron spin resonance method

1989 • 89 citations

Effect of superoxide dismutase on the autoxidation of substituted hydro- and semi-naphthoquinones

1990 • 80 citations

Role of Quinone-Mediated Generation of Hydroxyl Radicals in the Induction of Glutathione S-Transferase Gene Expression

1995 • 80 citations

Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression

1993 • 74 citations

Oxidation of phenolates and phenylenediamines by 2-alkononyl radicals produced from 1,2-dihydroxy- and 1-hydroxy-2-alkoxyalkyl radicals

1979 • 73 citations

Mechanism for the potentiation of oxygen toxicity by disulfiram.

1980 • 66 citations

Production of reactive oxygen species due to metabolic activation of butylated hydroxyanisole

1989 • 61 citations

DNA damage in forestomach epithelium from male F344 rats following oral administration of tert-butylquinone, one of the forestomach metabolites of 3-BHA

1991 • 53 citations

Role of quinone-iron(III) interaction in NADPH-dependent enzymic generation of hydroxyl radicals

1992 • 46 citations

Studies on substrate specificity of the hog liver flavin-containing monooxygenase

1987 • 45 citations

[66] Modulation of cellular glutathione and protein thiol status during quinone metabolism

1990 • 40 citations

Solvent effects on the redox potentials of benzoquinone

1985 • 39 citations

[8] Quantitative determination of thiol groups in lowand high molecular weight compounds by electron paramagnetic resonance

1995 • 35 citations

Oxygen radical formation during prostaglandin H synthase-mediated biotransformation of butylated hydroxyanisole

1993 • 34 citations

[8] Oxygen radicals generation and DNA scission by anticancer and synthetic quinones

1994 • 30 citations

Enhancement by disulfiram (Antabuse) of toxic effects of 95 to 97% O2 on the rat lung.

1979 • 22 citations

Substituent and solvent perturbations for h.f.s. constants in 1,4-semiquinones. The additivity principle

1975 • 6 citations