Electron Shuttle between Membrane-Bound Cytochrome P450 3A4 andb₅Rules Uncoupling Mechanisms

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Reactions and significance of cytochrome P-450 enzymes

1991 • 596 citations

Enzyme Topology of Intracellular Membranes

1977 • 390 citations

Structural aspects of the membrane of the endoplasmic reticulum

1975 • 351 citations

On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction.

1984 • 324 citations

Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome b5

1993 • 160 citations

Synthesis of functional mouse cytochromes P-450 P1 and chimeric P-450 P3-1 in the yeast Saccharomyces cerevisiae

1988 • 132 citations

The Role of NADH in Uncoupled Microsomal Monoxygenations

1974 • 131 citations

Metabolic switching in cyctochrome P-450cam: deuterium isotope effects on regiospecificity and the monooxygenase/oxidase ratio

1987 • 120 citations

The Nature of the Heme Binding in Microsomal Cytochrome b5

1960 • 113 citations

Direct evidence for electron transfer from ferrous cytochrome b5 to the oxyferrous intermediate of liver microsomal cytochrome P-450 LM2.

1981 • 109 citations

Twenty-five Years of P450cam Research

1995 • 107 citations

Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5.

1985 • 104 citations

Optimization of yeast‐expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH‐cytochrome P450 reductase and cytochrome b₅

1992 • 88 citations

Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

1982 • 86 citations

On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5.

1984 • 86 citations

NADH- and NADPH-Dependent Reconstituted p-Nitroanisole O-Demethylation System Containing Cytochrome P-450 with High Affinity for Cytochrome b51

1980 • 73 citations

Cytochrome b₅ as Electron Donor for Oxy‐cytochrome P‐450

1981 • 62 citations

Properties of the oxygenated form of liver microsomal cytochrome P-450.

1983 • 56 citations

Quantification of NADPH: cytochrome P-450 reductase in liver microsomes by a specific radioimmunoassay technique

1983 • 56 citations

Purification to homogeneity and enzymological characterization of a functional covalent complex composed of cytochromes P-450 isozyme 2 and b5 from rabbit liver.

1987 • 54 citations

The identification of the heat-stable microsomal protein required for methoxyflurane metabolism as cytochrome b5.

1984 • 49 citations

METALLOPORPHYRINS

1940 • 46 citations

Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids

1995 • 43 citations

Xenobiotic metabolism in humanized yeast: engineered yeast cells producing human NADP H-cytochrome P-450 reductase, cytochrome b5, epoxide hydrolase and P-450s

1993 • 36 citations

Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity

1993 • 25 citations

The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism

1994 • 14 citations

[10] In vitro assessment of various cytochromes P450 and glucuronosyltransferases using the antiarrhythmic propafenone as a probe drug

1996 • 10 citations