Peroxynitrite

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

The mitochondrial permeability transition

1995 • 2,412 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Strategies of antioxidant defense

1993 • 1,963 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor

1992 • 1,063 citations

[23] Oxidative chemistry of peroxynitrite

1994 • 981 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite

1997 • 778 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1992 • 758 citations

Glutathione: Toxicological Implications

1990 • 750 citations

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 • 726 citations

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

1996 • 719 citations

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

1994 • 718 citations

Peroxynitrite-mediated oxidation of dihydrorhodamine 123

1994 • 716 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

1994 • 699 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1997 • 680 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

1996 • 626 citations

Peroxynitrite‐mediated oxidative protein modifications

1995 • 611 citations

Peroxynitrite Reaction with Carbon Dioxide/Bicarbonate: Kinetics and Influence on Peroxynitrite-Mediated Oxidations

1996 • 583 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

1985 • 512 citations

Mitochondria and programmed cell death: back to the future

1996 • 508 citations

Rapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity

1995 • 506 citations

A Direct Demonstration of the Catalytic Action of Superoxide Dismutase through the Use of Pulse Radiolysis

1972 • 489 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study

1995 • 389 citations

Tyrosine Modification by Reactive Nitrogen Species: A Closer Look

1995 • 371 citations

Peroxynitrite-induced luminol chemiluminescence

1993 • 371 citations

Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide

1995 • 369 citations

Superoxide as an intracellular radical sink

1993 • 356 citations

The chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid

1968 • 348 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 • 320 citations

Metabolic Fate of Peroxynitrite in Aqueous Solution

1997 • 318 citations

Peroxynitrite-induced Apoptosis in HL-60 Cells

1995 • 300 citations

The role of intracellular oxidants in apoptosis

1995 • 294 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

The Comparative Toxicity of Nitric Oxide and Peroxynitrite to Escherichia coli

1995 • 286 citations

Acceleration of Peroxynitrite Oxidations by Carbon Dioxide

1996 • 277 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

A precise method for the determination of whole blood and plasma sulfhydryl groups

1979 • 261 citations

Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase

1991 • 259 citations

Pathways of peroxynitrite oxidation of thiol groups

1997 • 254 citations

Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins

1990 • 249 citations

Synthesis of Peroxynitrite in a Two-Phase System Using Isoamyl Nitrite and Hydrogen Peroxide

1996 • 227 citations

Characterization of Sulfur-centered Radical Intermediates Formed during the Oxidation of Thiols and Sulfite by Peroxynitrite

1996 • 222 citations

Peroxynitrite versus Hydroxyl Radical: The Role of Nitric Oxide in Superoxide‐Dependent Cerebral Injury^a

1994 • 215 citations

Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents

1994 • 212 citations

Turning on the respiratory burst

1990 • 211 citations

Superoxide and nitric oxide cooperation in hypoxia/ reoxygenation-induced neuron injury

1993 • 207 citations

Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver

1995 • 204 citations

Peroxynitrite-induced Accumulation of Cyclic GMP in Endothelial Cells and Stimulation of Purified Soluble Guanylyl Cyclase

1995 • 199 citations

The formation of peroxynitrite in vivo from nitric oxide and superoxide

1995 • 197 citations

A practical method for preparing peroxynitrite solutions of low ionic strength and free of hydrogen peroxide

1995 • 197 citations

Peroxynitrite Causes DNA Nicks in Plasmid pBR322

1995 • 185 citations

Peroxynitrite: A two-faced metabolite of nitric oxide

1997 • 179 citations

Nitric oxide (NO) protects against cellular damage by reactive oxygen species

1995 • 176 citations

Spin-Trapping Studies of Peroxynitrite Decomposition and of 3-Morpholinosydnonimine N-Ethylcarbamide Autooxidation: Direct Evidence for Metal-Independent Formation of Free-Radical Intermediates

1994 • 171 citations

Peroxynitrite‐mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia‐reperfusion injury

1995 • 164 citations

Peroxynitrite Causes Apoptosis in Rat Thymocytes

1995 • 153 citations

Nitric oxide release from the isolated guinea pig heart

1988 • 153 citations

Peroxynitrite‐mediated oxidation of albumin to the protein‐thiyl free radical

1994 • 146 citations

Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A

1994 • 143 citations

Direct and indirect oxidations by peroxynitrite, neither involving the hydroxyl radical

1996 • 140 citations

Peroxynitrite Formed by Simultaneous Nitric Oxide and Superoxide Generation Causes Cyclosporin‐A‐Sensitive Mitochondrial Calcium Efflux and Depolarisation

1995 • 140 citations

Peroxynitrite Inactivates Thiol-Containing Enzymes of Trypanosoma cruzi Energetic Metabolism and Inhibits Cell Respiration

1994 • 126 citations

Glutathione Protects Astrocytes from Peroxynitrite-Mediated Mitochondrial Damage: Implications for Neuronal/ Astrocytic Trafficking and Neurodegeneration

1996 • 124 citations

Biomimetic Synthesis of the Putative Cytotoxin Peroxynitrite, ONOO-, and Its Characterization as a Tetramethylammonium Salt

1994 • 123 citations

Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite

1996 • 116 citations

Endogenous Peroxynitrite Is Involved in the Inhibition of Mitochondrial Respiration in Immuno-Stimulated J774.2 Macrophages

1995 • 109 citations

The Importance of Superoxide in Nitric Oxide-Dependent Toxicity

1996 • 105 citations

On the involvement of a mitochondrial pore in reperfusion injury

1993 • 86 citations

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

1996 • 82 citations

Inhibition of Peroxynitrite-Mediated Oxidation of Glutathione by Carbon Dioxide

1997 • 72 citations

Peroxynitrite Stimulates the Pyridine Nucleotide-Linked Ca²⁺ Release from Intact Rat Liver Mitochondria

1996 • 72 citations

Induction of the mitochondrial permeability transition by peroxynitrite

1997 • 58 citations

Insensitivity of the Rate of Decomposition of Peroxynitrite to Changes in Viscosity; Evidence against Free Radical Formation

1996 • 57 citations

Peroxynitrite-Dependent Chemiluminescence of Amino Acids, Proteins, and Intact Cells

1995 • 56 citations

Exposure to the parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) and nitric oxide simultaneously causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation

1996 • 42 citations

Quantitation of Protein Tyrosine, 3-Nitrotyrosine, and 3-Aminotyrosine Utilizing HPLC and Intrinsic Ultrviolet Absorbance

1995 • 32 citations

Enhanced Induction of the Mitochondrial Permeability Transition Following Acute Menadione Administration

1995 • 26 citations

Detection of Peroxynitrite

1995 • 24 citations