Suppression ofCYP1A1Transcription by H2O2Is Mediated by Xenobiotic-Response Element

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

1980 • 1,277 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

1982 • 520 citations

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

1988 • 455 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.

1992 • 354 citations

Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes

1996 • 351 citations

Cloning and expression of a human Ah receptor cDNA.

1993 • 334 citations

Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon.

1982 • 280 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).

1994 • 249 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

A general mechanism for transcriptional synergy by eukaryotic activators

1995 • 185 citations

Regulation of cytochrome P1-450 gene transcription by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells.

1984 • 166 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.

1993 • 160 citations

Cooperative Interaction between AhR·Arnt and Sp1 for the Drug-inducible Expression of CYP1A1 Gene

1996 • 160 citations

Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation.

1994 • 160 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

HumanP₁-450gene sequence and correlation of mRNA with genetic differences in benzo(a]pyrene metabolism

1985 • 141 citations

Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene.

1986 • 140 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress.

1994 • 122 citations

Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin

1991 • 110 citations

Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.

1996 • 109 citations

Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment.

1991 • 104 citations

Organization and function of a dioxin-responsive enhancer.

1990 • 99 citations

A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.

1990 • 96 citations

Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1992 • 96 citations

P450 and Human Cancer

1991 • 94 citations

Transcriptional Activation by the Mouse Ah Receptor.

1995 • 80 citations

The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells

1992 • 75 citations

Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice.

1985 • 72 citations

Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.

1990 • 64 citations

Multiple DNA-binding factors interact with overlapping specificities at the aryl hydrocarbon response element of the cytochrome P450IA1 gene.

1990 • 60 citations

DNA binding activity of the glucocorticoid receptor is sensitive to redox changes in intact cells

1995 • 55 citations

Aryl hydrocarbon (Ah) receptor DNA-binding activity. Sequence specificity and Zn2+ requirement.

1990 • 49 citations

Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.

1994 • 47 citations

The DNA Binding of Purified Ah Receptor Heterodimer Is Regulated by Redox Conditions

1995 • 43 citations

Alcohol-induced oxidative stress in rat liver

1991 • 38 citations

Effect of Insulin on Hydrogen Peroxide Production by Human Polymorphonuclear Leukocytes

1995 • 36 citations

The effects of ether anaesthesia on oxidative stress in rats — dose response

1993 • 33 citations

Dioxin-inducible, Ah receptor-dependent transcription in vitro.

1990 • 30 citations

Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence—a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription

1994 • 30 citations

Regulation of protein kinase enzymatic activity in Jurkat T cells during oxidative stress uncoupled from protein tyrosine kinases: role of oxidative changes in protein kinase activation requirements and generation of second messengers.

1994 • 28 citations

Structure and function of the Ah receptor: Sulfhydryl groups required for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to cytosolic receptor from rodent livers

1987 • 25 citations

Oxidative Stress Causes a Protein Kinase C-independent Increase of Paracellular Permeability in an In Vitro Epithelial Model

1993 • 20 citations

Regulation of colony-stimulating factor 1-induced proliferation by heterotrimeric Gi2 proteins

1995 • 19 citations

Mapping sequence specific DNA-protein interactions: a versatile, quantitative method and its application to transcription factor XF1 1 1Edited by M. Yaniv

1997 • 8 citations