The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

1990 • 827 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Structure and expression of a human oxytocin receptor

1992 • 622 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation

1991 • 454 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Structural and functional studies on platelet-derived growth factor.

1992 • 335 citations

The molecular action of tumor necrosis factor-alpha

1991 • 279 citations

Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum

1991 • 242 citations

Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.

1992 • 232 citations

Leukocytic Oxygen Activation and Microbicidal Oxidative Toxin

1989 • 225 citations

A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore.

1991 • 184 citations

Generation of H2O2 in biomembranes

1982 • 158 citations

Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

1987 • 148 citations

Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells

1995 • 137 citations

Reduced nicotinamide adenine dinucleotide phosphate oxidase in adipocyte plasma membrane and its activation by insulin

1977 • 127 citations

Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells

1992 • 119 citations

Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.

1992 • 114 citations

Superoxide anion increases intracellular pH, intracellular free calcium, and arachidonate release in human amnion cells

1991 • 106 citations

Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells

1990 • 105 citations

The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig.

1988 • 100 citations

Stimulation of NADH oxidase activity from rat liver plasma membranes by growth factors and hormones is decreased or absent with hepatoma plasma membranes

1992 • 90 citations

NADPH‐dependent generation of H₂O₂ in a thyroid particulate fraction requires Ca²⁺

1985 • 74 citations

Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells.

1993 • 69 citations

Interactions of FGFs with target cells

1992 • 60 citations

The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase

1991 • 58 citations

Recombinant human tumor necrosis factor does not inhibit lipoprotein lipase in primary cultures of isolated human adipocytes

1988 • 48 citations

Structural heterogeneity of membrane receptors and GTP‐binding proteins and its functional consequences for signal transduction

1991 • 44 citations

The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.

1986 • 39 citations

Influences of variation in total energy intake and dietary composition on regulation of fat cell lipolysis in ideal-weight subjects.

1987 • 39 citations

Mediation of the antilipolytic and lipogenic effects of insulin in adipocytes by intracellular accumulation of hydrogen peroxide

1980 • 38 citations

Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor.

1990 • 38 citations

Chemiluminescent determination of adenosine, inosine, and hypoxanthine/xanthine

1987 • 34 citations

Counterregulatory control of intracellular hydrogen peroxide production by insulin and lipolytic hormones in isolated rat epididymal fat cells: a role of free fatty acids

1982 • 28 citations

Stimulation of pyruvate dehydrogenase activity in adipocytes by oxytocin: Evidence for mediation of the insulin-like effect by endogenous hydrogen peroxide independent of glucose transport

1982 • 24 citations

Generation of hydrogen peroxide by cerebral‐cortex synaptosomes

1989 • 23 citations

Mechanism of glucagon activation of adenylate cyclase in the presence of Mn²⁺

1983 • 13 citations