Physical and Functional Sensitivity of Zinc Finger Transcription Factors to Redox Change

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Zinc fingers: Gilt by association

1988 • 799 citations

NHLBI funding policies. Enhancing stability, predictability, and cost control.

1994 • 765 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

1992 • 533 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

1994 • 531 citations

Reactive oxygen species and antioxidant vitamins: Mechanisms of action

1994 • 531 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

1982 • 464 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Oxygen-derived radicals: a link between reperfusion injury and inflammation.

1987 • 389 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection

1994 • 379 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.

1991 • 320 citations

Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.

1994 • 310 citations

A Myogenic Cell Line with Altered Serum Requirements for Differentiation

1977 • 305 citations

Spectrophotometric assay of thiols

1987 • 301 citations

Interaction between transcription factors Spl and YY1

1993 • 282 citations

Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

1993 • 275 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

The retinoblastoma gene product regulates Sp1-mediated transcription.

1992 • 253 citations

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl

1991 • 252 citations

Antioxidant response element

1994 • 245 citations

Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum

1991 • 242 citations

Redox redux: The control of oxidative stress responses

1991 • 242 citations

Toward rules relating zinc finger protein sequences and DNA binding site preferences.

1992 • 223 citations

The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.

1993 • 212 citations

Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity.

1992 • 209 citations

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes

1993 • 206 citations

Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression.

1994 • 188 citations

Free radicals and ischemic tissue injury

1990 • 187 citations

Regulation of Tyrosine Hydroxylase Gene Expression in the Rat Carotid Body by Hypoxia

1992 • 186 citations

Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters

1988 • 183 citations

Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites.

1992 • 181 citations

Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture

1989 • 176 citations

Electrostatic influence of local cysteine environments on disulfide exchange kinetics

1981 • 167 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

The DNA‐Binding Efficiency of Sp1 is Affected by Redox Changes

1994 • 156 citations

Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2-dibutyryl cyclic amp increase the rate of transcription and change the stability of lactate dehydrogenase a subunit messenger RNA in rat C6 glioma cells.

1983 • 146 citations

Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Sp1

1993 • 139 citations

Zinc Fingers

1993 • 137 citations

Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.

1984 • 131 citations

Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1.

1992 • 131 citations

Multiple elements within the 5' distal enhancer of the mouse heme oxygenase-1 gene mediate induction by heavy metals.

1994 • 130 citations

Reduction of a conserved Cys is essential for Myb DNA-binding

1992 • 129 citations

The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner.

1992 • 127 citations

Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene.

1993 • 125 citations

Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat.

1993 • 124 citations

Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter

1989 • 123 citations

Fnr mutants that activate gene expression in the presence of oxygen

1991 • 110 citations

Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport.

1993 • 106 citations

Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells

1987 • 101 citations

Rapid action of insulin and cyclic AMP in the regulation of functional messenger RNA coding for glucokinase in rat liver.

1984 • 86 citations

Positive regulation of the skeletal alpha-actin gene by Fos and Jun in cardiac myocytes.

1992 • 86 citations

Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes.

1994 • 83 citations

Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.

1992 • 80 citations

Ischemic induction of protooncogene expression in gerbil brain.

1991 • 77 citations

Thiol/disulfide exchange between 3-hydroxy-3-methylglutaryl-CoA reductase and glutathione. A thermodynamically facile dithiol oxidation.

1988 • 77 citations

Polymerase chain reaction based assay to detect allelic loss in human DNA: loss of β-interleron gene in chronic myelogeneous leukemia

1990 • 77 citations

T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites

1993 • 74 citations

Metallothionein IIA is up-regulated by hypoxia in human A431 squamous carcinoma cells.

1994 • 63 citations

Role of Zinc-Coordination and of the Glutathione Redox Couple in the Redox Susceptibility of Human Transcription Factor Sp1

1994 • 63 citations

The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants

1993 • 62 citations

The regulation of glutathione peroxidase gene expression by oxygen tension in cultured human cardiomyocytes

1992 • 58 citations

Cooperative DNA Binding of the Human HoxB5 (Hox-2.1) Protein Is Under Redox Regulation In Vitro

1993 • 55 citations

Molecular structure of the human muscle-specific enolase gene (ENO3)

1991 • 46 citations

Oxygen modulates prostacyclin synthesis in ovine fetal pulmonary arteries by an effect on cyclooxygenase.

1992 • 39 citations

Transcriptional regulation of the pyruvate kinase erythroid-specific promoter.

1993 • 36 citations

Cerebral ischemia induces transient intracellular redistribution and intranuclear translocation of the raf proto-oncogene product in hippocampal pyramidal cells

1991 • 29 citations

Cellular Thiols as a Determinant of Responsiveness to Menadione in Cardiomyocytes

1994 • 24 citations

Mithramycin Selectively Inhibits the Transcriptional Activity of a Transfected Human C-myc Gene

1990 • 18 citations

Regulation of the Myoblast-specific Expression of the Human β-Enolase Gene

1995 • 17 citations

Distribution and metabolism of aflatoxin B₁ in the marmoset monkey (Callithrix jacchus)

1993 • 16 citations

The c-fos cyclic AMP-responsive element conveys constitutive expression to a tissue-specific promoter.

1990 • 13 citations

The Degradation of Phosphoenolpyruvate Carboxykinase (GTP) mRNA Is Regulated by Cyclic AMP But Not by Dexamethasone

1994 • 5 citations