Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1

1946 • 2,239 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

THIOREDOXIN

1985 • 1,885 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide

1995 • 430 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 357 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones

1996 • 285 citations

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.

1990 • 283 citations

Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum

1991 • 242 citations

Redox redux: The control of oxidative stress responses

1991 • 242 citations

Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.

1995 • 240 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

Cellular Defenses Against Damage From Reactive Oxygen Species

1995 • 220 citations

Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response.

1991 • 215 citations

Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.

1996 • 203 citations

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

1994 • 174 citations

Electrostatic influence of local cysteine environments on disulfide exchange kinetics

1981 • 167 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1985 • 158 citations

Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells

1995 • 115 citations

High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein

1991 • 99 citations

IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor.

1988 • 90 citations

Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

1992 • 77 citations

Modulation of glucocorticoid receptor function by protein kinase A

1992 • 74 citations

Sulfhydryl-modifying reagents reversibly inhibit binding of glucocorticoid-receptor complexes to DNA-cellulose

1984 • 71 citations

Role of ATL-derived factor (ADF) in the normal and abnormal cellular activation: Involvement of dithiol related reduction

1990 • 64 citations

[39] Glucocorticoid receptor thiols andsteroid-binding activity

1995 • 46 citations

Membrane Oxidative Metabolism of Human Eosinophilic Cell Line EoL-1 in Response to Phorbol Diester and Formyl Peptide: Synergistic Augmentation by Interferon-γ Tumor Necrosis Factor

1989 • 32 citations

Modulation of glucocorticoid-inducible gene expression by metal ions.

1996 • 26 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 23 citations

The effects of Mevinolin on The Thiol/Disulfide Exchange between 3-Hydroxy-3-methyglutaryl-coenzyme A Reductase and Glutathione

1989 • 21 citations

ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction.

1994 • 21 citations

Paradoxical derepression of collagenase gene expression by the antirheumatic gold compound aurothiomalate.

1994 • 8 citations

Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations.

1995 • 6 citations