Redox Potential Controls the Structure and DNA Binding Activity of the Paired Domain

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Calculation of protein extinction coefficients from amino acid sequence data

1989 • 5,198 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

1974 • 2,040 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Influence of PAX6 Gene Dosage on Development: Overexpression Causes Severe Eye Abnormalities

1996 • 435 citations

Pax: A murine multigene family of paired box-containing genes

1991 • 427 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1993 • 391 citations

Stabilization of the ribonuclease S‐peptide α‐helix by trifluoroethanol

1986 • 381 citations

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1993 • 373 citations

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.

1994 • 364 citations

Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli.

1980 • 364 citations

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

1994 • 361 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

The role of Pax-1 in axial skeleton development

1994 • 343 citations

Pax genes and their roles in cell differentiation and development

1996 • 325 citations

Crystal structure of a paired domain-DNA complex at 2.5 å resolution reveals structural basis for pax developmental mutations

1995 • 325 citations

Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.

1992 • 298 citations

Dysgenesis of cephalic neural crest derivatives in Pax7−/− mutant mice

1996 • 297 citations

The molecular basis of the undulated/Pax-1 mutation

1991 • 273 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

1990 • 244 citations

PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms’ tumors

1992 • 223 citations

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

1993 • 212 citations

Cooperative interactions between paired domain and homeodomain

1996 • 205 citations

Activation of transcription factor IIIC by the adenovirus E1A protein

1988 • 197 citations

Pax6: more than meets the eye

1995 • 195 citations

Peptide .alpha.-helicity in aqueous trifluoroethanol: correlations with predicted .alpha.-helicity and the secondary structure of the corresponding regions of bovine growth hormone

1990 • 192 citations

Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8

1997 • 153 citations

DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein.

1993 • 146 citations

Redox Regulation of the DNA Binding Activity in Transcription Factor PEBP2

1997 • 143 citations

An Alternative Splicing Event in the Pax-3 Paired Domain Identifies the Linker Region as a Key Determinant of Paired Domain DNA-Binding Activity

1996 • 102 citations

Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells.

1996 • 100 citations

Topology of the calmodulin-melittin complex 1 1Edited by P.E. Wright

1998 • 95 citations

The role of BSAP (Pax-5) in B-cell development

1995 • 87 citations

PAX5 expression correlates with increasing malignancy in human astrocytomas.

1995 • 79 citations

Hydrogen peroxide generation and its regulation in FRTL-5 and porcine thyroid cells.

1992 • 71 citations

Identification of DNA recognition sequences for the Pax3 paired domain

1995 • 64 citations

Thyrotropin-induced hydrogen peroxide production in FRTL-5 thyroid cells is mediated not by adenosine 3',5'-monophosphate, but by Ca2+ signaling followed by phospholipase-A2 activation and potentiated by an adenosine derivative.

1995 • 63 citations

Pax 8 expression in primary cultured dog thyrocyte is increased by cyclic AMP

1996 • 54 citations

A new Pax gene, Pax-9, maps to mouse Chromosome 12

1993 • 51 citations

Determination of Functional Domains of the Human Transcription Factor PAX8 Responsible for its Nuclear Localization and Transactivating Potential

1997 • 51 citations

A bacterially expressed single-chain Fv construct from the 2B4 T-cell receptor.

1993 • 43 citations

Structural Studies of Mutant Glucocorticoid Receptor Transactivation Domains Establish a Link between Transactivation Activity in Vivo and α-Helix-Forming Potential in Vitro

1996 • 43 citations

Cross-linking of HLA class II antigens modulates the release of tumor necrosis factor-alpha by the EBV-B lymphoblastoid cell line JY.

1993 • 40 citations

Making of a Schwann

1996 • 38 citations

Increase in Ref-1 mRNA and Protein by Thyrotropin in Rat Thyroid FRTL-5 Cells

1997 • 38 citations

A network of specific minor-groove contacts is a common characteristic of paired-domain-DNA interactions

1996 • 15 citations