Effect of Reactive Oxygen Species on Iron Regulatory Protein Activitya

Strategies of antioxidant defense

1993 • 1,963 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

The interleukin‐1 family: 10 years of discovery ¹

1994 • 784 citations

Ischaemia-reperfusion injury

1994 • 731 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Free radical formation by antitumor quinones

1989 • 419 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Rapid responses to oxidative stress mediated by iron regulatory protein.

1995 • 331 citations

Aconitase, a two‐faced protein: enzyme and iron regulatory factor ^{1 2}

1993 • 269 citations

LIVER ISCHEMIA AND REPERFUSION INDUCES A SYSTEMIC INFLAMMATORY RESPONSE THROUGH KUPFFER CELL ACTIVATION

1996 • 258 citations

The Role of Iron in Oxygen-Mediated Toxicities

1992 • 257 citations

Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

1996 • 194 citations

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation

1986 • 187 citations

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase.

1994 • 176 citations

Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

1997 • 164 citations

Sources and role of iron in lipid peroxidation

1993 • 152 citations

Oxidative Stress Induces Activation of a Cytosolic Protein Responsible for Control of Iron Uptake

1995 • 146 citations

Recombinant iron‐regulatory factor functions as an iron‐responsive‐element‐binding protein, a translational repressor and an aconitase

1993 • 144 citations

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?

1992 • 133 citations

Iron-Dependent Regulation of Ferritin and Transferrin Receptor Expression by the Iron-Responsive Element Binding Protein

1992 • 132 citations

Superoxide and hydrogen peroxide‐dependent inhibition of iron regulatory protein activity: a protective stratagem against oxidative injury

1996 • 127 citations

Iron Overload: Causes and Consequences

1987 • 120 citations

Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.

1993 • 103 citations

In vivo and in vitro modulation of the mRNA‐binding activity of iron‐regulatory factor

1992 • 77 citations

Newly delivered transferrin iron and oxidative cell injury

1997 • 70 citations

Some aspects of glycogen metabolism following reversible or irreversible liver ischemia

1964 • 66 citations

Iron regulatory proteins 1 and 2

1996 • 56 citations

Nitric‐Oxide‐Mediated Activation of Iron‐Regulatory Protein Controls Hepatic Iron Metabolism During Acute Inflammation

1995 • 53 citations

An overview of iron metabolism at a molecular level

1989 • 46 citations

Nitric oxide and the post-transcriptional control of cellular iron traffic

1994 • 46 citations

Superoxide-dependent redox cycling of citrate-Fe3+: Evidence for a superoxide dismutaselike activity

1987 • 30 citations

Iron-Dependent Regulation of Ferritin and Transferrin Receptor Expression by the Iron-Responsive Element Binding Protein

1992 • 8 citations

Iron Overload: Causes And Consequences

1987 • 4 citations