Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

1993 • 385 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Failure to synthesize the T Cell CD3-? chain: Structure and function of a partial T cell receptor complex

1988 • 351 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Alterations in the signal‐transducing molecules of T cells and nk cells in colorectal tumor‐infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease

1995 • 217 citations

3-Aminopropyltriethoxysilane (APES): a new advance in section adhesion.

1987 • 192 citations

Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.

1989 • 186 citations

N-Acetylcysteine-promoted Survival of PC12 Cells Is Glutathione-independent but Transcription-dependent

1995 • 174 citations

Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.

1995 • 168 citations

Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.

1994 • 168 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex.

1995 • 150 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

1994 • 139 citations

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction.

1994 • 113 citations

The metabolism of N-acetylcysteine by human endothelial cells

1991 • 95 citations

Regulatory mechanisms for production of IFN-gamma and TNF by antitumor T cells or macrophages in the tumor-bearing state.

1995 • 93 citations

A permeabilized cell system identifies the endoplasmic reticulum as a site of protein degradation.

1991 • 90 citations

Tumor escape mechanisms from immunosurveillance: induction of unresponsiveness in a specific MHC-restricted CD4⁺; human T cell clone by the autologous MHC class II⁺ melanoma

1993 • 90 citations

Rapid turnover of the CD3ζ chain independent of the TCR-CD3 complex in normal T cells

1995 • 78 citations

Splenic Macrophages From Tumor-Bearing Mice Co-Expressing MAC-1 and MAC-2 Antigens Exert Immunoregulatory Functions Via Two Distinct Mechanisms

1991 • 69 citations

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

1990 • 67 citations

Aberrant antigen presentation by macrophages from tumor-bearing mice is involved in the down-regulation of their T cell responses.

1995 • 63 citations

Regulation of selective protein degradation in the endoplasmic reticulum by redox potential.

1993 • 58 citations

T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity.

1995 • 57 citations

High Frequency of Cancer Patients with Abnormal Assembly of the T Cell Receptor‐CD3 Complex in Peripheral Blood T Lymphocytes

1994 • 52 citations

Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice.

1995 • 47 citations

Transforming Growth Factor‐β CD4⁺ T cells Tumor‐bearing state Immunosuppression Enhanced Production of TGF‐β and a Progressive Increase in TGF‐β Susceptibility of Anti‐tumor CD4⁺ T Cell Function

1993 • 45 citations

Significance of Suppressor Macrophages for Immunosurveillance of Tumor-Bearing Mice<xref ref-type="fn" rid="FN2">2</xref>

1987 • 43 citations

Transforming growth factor-β (TGF-β)-mediated immunosuppression in the tumor-bearing state : enhanced production of TGF-β and a progressive increase in TGF-β susceptibility of anti-tumor CD4[+] T cell function

1993 • 20 citations

Different cytoplasmic structure of the CD3ζ family dimer modulates the activation signal and function of T cells

1994 • 18 citations

Do Structural Changes of T Cell Receptor Complex Occur in Tumor‐bearing State?

1995 • 15 citations

Promotion of Macrophage-Stimulated Autoreactive T Cell Proliferation by Interleukin-10: Counteraction of Macrophage Suppressor Activity During Tumor Growth

1995 • 11 citations

Modulation of Alloreactivity by Mac-1+, -2+, and -3+ Macrophages From Normal and Tumor-Bearing Hosts: Flow Cytofluorometrically Separated Macrophages

1990 • 11 citations