Insights into cancer from transgenic mouse models

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The multistep nature of cancer

1993 • 1,872 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Ligand-activated site-specific recombination in mice.

1996 • 885 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

1997 • 851 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1996 • 806 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1994 • 777 citations

Tumor suppressor genes

1991 • 775 citations

Antioncogenes and human cancer.

1993 • 772 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene

1997 • 764 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

The SCID Mouse Mutant: Definition, Characterization, and Potential Uses

1991 • 743 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

1997 • 580 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Second primary neoplasms in patients with retinoblastoma

1986 • 563 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

1995 • 551 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.

1997 • 537 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer.

1994 • 534 citations

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

1994 • 519 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1998 • 445 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Amplification and expression of the human cyclin D gene in esophageal cancer.

1992 • 411 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

1997 • 405 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1998 • 381 citations

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1995 • 378 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Mutation of E2f-1 Suppresses Apoptosis and Inappropriate S Phase Entry and Extends Survival of Rb-Deficient Mouse Embryos

1998 • 375 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Loss of Apc+ in intestinal adenomas from Min mice.

1994 • 373 citations

Transgenic Mice as Probes into Complex Systems

1989 • 368 citations

Mutation in the Mismatch Repair Gene Msh6 Causes Cancer Susceptibility

1997 • 359 citations

Site-specific recombinases: tools for genome engineering

1993 • 353 citations

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

1998 • 351 citations

Apoptosis and the cell cycle

1995 • 334 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.

1994 • 325 citations

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

1998 • 316 citations

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

1994 • 315 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

1994 • 295 citations

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

1994 • 295 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

A novel protein with strong homology to the tumor suppressor p53

1997 • 282 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

1996 • 271 citations

Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivo

1997 • 270 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Retinoblastoma in transgenic mice

1990 • 246 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression

1998 • 242 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Mutation and altered expression of p16^ in human cancer

1994 • 234 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

1998 • 220 citations

Essential role for p53-mediated transcription in E1A-induced apoptosis.

1995 • 219 citations

Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.

1994 • 219 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

The p53 response to ionising radiation in adult and developing murine tissues.

1996 • 206 citations

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors.

1996 • 206 citations

Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

1988 • 204 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes

1993 • 185 citations

Inducible gene expression systems for higher eukaryotic cells

1994 • 178 citations

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1996 • 173 citations

Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

1996 • 171 citations

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

1997 • 168 citations

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.

1996 • 165 citations

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53

1998 • 159 citations

Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer

1991 • 158 citations

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

1994 • 155 citations

Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1

1997 • 151 citations

p53 and the Li-Fraumeni syndrome

1993 • 151 citations

Interaction of p53 with Its Consensus DNA-Binding Site

1995 • 146 citations

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

1998 • 138 citations

Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites.

1995 • 132 citations

A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6

1993 • 128 citations

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.

1996 • 123 citations

Overexpression of cyclin D1 in mouse skin carcinogenesis.

1993 • 122 citations

Bovine papillomavirus genome elicits skin tumours in transgenic mice

1986 • 121 citations

Inbred Strains of Mice

1979 • 119 citations

Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.

1995 • 114 citations

Traps to catch unwary oncogenes

1998 • 113 citations

TUMOR SUPPRESSOR GENE MUTATIONS IN MICE

1996 • 104 citations

Increased Tumor Proliferation and Genomic Instability without Decreased Apoptosis in MMTV-ras Mice Deficient in p53

1997 • 93 citations

Chromosome mapping of murine susceptibility loci to liver carcinogenesis.

1993 • 92 citations

No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma

1998 • 84 citations

Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.

1996 • 82 citations

Tissue-specific inactivation of p53 tumor suppression in the mouse.

1996 • 78 citations

Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma.

1995 • 75 citations

An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.

1995 • 65 citations

V(D)J recombination is not required for the development of lymphoma in p53-deficient mice.

1998 • 63 citations

Expression pattern of the cell adhesion molecules E-cadherin, P-cadherin and α6β4 integrin is altered in pre-malignant skin tumors of p53-deficient mice

1996 • 45 citations

Acceleration of B-lymphoid tumorigenesis in E mu-myc transgenic mice by v-H-ras and v-raf but not v-abl.

1989 • 40 citations

Tumor suppressor mutations in mice: the next generation

1998 • 16 citations