Tumor spectrum analysis in p53-mutant mice

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Gain of function mutations in p53

1993 • 876 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Transgenic Mice as Probes into Complex Systems

1989 • 368 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

Analysis of the gene coding for the murine cellular tumour antigen p53.

1984 • 182 citations

p53 and the Li-Fraumeni syndrome

1993 • 151 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

The Developmental Biology Of T Lymphocytes

1988 • 98 citations