Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Current protocols in molecular biology

1988 • 4,543 citations

The Neural Crest

1999 • 2,996 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

Von Recklinghausen Neurofibromatosis

1981 • 1,336 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Neurofibromatosis. Conference statement, National Institute of Health development conference

1988 • 1,240 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

1990 • 1,107 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

1990 • 1,085 citations

Neural Crest Cells Contribute to Normal Aorticopulmonary Septation

1983 • 1,083 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

Neurofibromatosis, Phenotype, Natural History, and Pathogenesis

1992 • 789 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1992 • 648 citations

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues.

1994 • 634 citations

The neurocristopathiesA unifying concept of disease arising in neural crest maldevelopment

1974 • 591 citations

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1992 • 583 citations

A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice

1987 • 487 citations

Loss of The Normal NF1 Allele from the Bone Marrow of Children with Type 1 Neurofibromatosis and Malignant Myeloid Disorders

1994 • 456 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1992 • 399 citations

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1993 • 393 citations

Role of neural crest in congenital heart disease.

1990 • 390 citations

An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes.

1993 • 384 citations

The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes

1992 • 309 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Malignancy in Neurofibromatosis

2015 • 276 citations

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos

1987 • 261 citations

Rapid, small-scale RNA isolation from tissue culture cells.

1991 • 216 citations

Neurofibromatosis, Phenotype, Natural History, and Pathogenesis

1992 • 207 citations

Identification and characterization of the neurofibromatosis type 1 protein product.

1991 • 204 citations

Persistent truncus arteriosus in the Splotch mutant mouse

1989 • 184 citations

Neurofibromatosis type 1 gene mutations in neuroblastoma

1993 • 157 citations

Loss of NF1 alleles in phaeochromocytomas from patients with type 1 neurofibromatosis

1992 • 157 citations

Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines

1993 • 144 citations

Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.

1993 • 143 citations

Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development

1992 • 120 citations

NF1: a prevalent cause of tumorigenesis in human cancers?

1993 • 101 citations

Tandem duplication within a neurofibromatosis type 1 (NF1) gene exon in a family with features of Watson syndrome and Noonan syndrome.

1993 • 88 citations

Differential Expression and Tissue Distribution of Type I and Type II Neurofibromins during Mouse Fetal Development

1994 • 81 citations

An alternatively-spliced mRNA in the carboxy terminus of the neurofibromatosis type 1 (NF1) gene is expressed in muscle

1993 • 68 citations

Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments

1993 • 67 citations

Bilateral Pheochromocytoma —Ganglioneuroma of the Adrenal in Type 1 Neurofibromatosis

1993 • 57 citations

Identification and characterization of sporadic and inherited mutations in exon 31 of the neurofibromatosis (NF1) gene

1993 • 46 citations

Recurrence of a nonsense mutation in the NF1 gene causing classical neurofibromatosis type 1

1991 • 40 citations

Adrenal medullary tumors and iris proliferation in a transgenic mouse model of neurofibromatosis.

1992 • 28 citations