Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Alleles of the APC gene: An attenuated form of familial polyposis

1993 • 621 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

Regulation of intestinal epithelial cell growth by transforming growth factor type beta.

1989 • 341 citations

Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients

1993 • 320 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection.

1990 • 241 citations

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.

1992 • 224 citations

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.

1992 • 223 citations

Association between wild type and mutant APC gene products.

1993 • 194 citations

Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.

1990 • 179 citations

Dimer formation by an N-terminal coiled coil in the APC protein.

1993 • 175 citations

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).

1993 • 149 citations

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)

1992 • 120 citations

In vivo measurements in familial polyposis: kinetics and location of proliferating cells in colonic adenomas.

1982 • 56 citations

Demonstration of promoter activity and alternative splicing in the region 5' to exon 1 of the APC gene.

1994 • 51 citations

APC gene messenger RNA: novel isoforms that lack exon 7.

1993 • 34 citations

Morphological basis of multistep process in experimental colonic carcinogenesis

1982 • 20 citations