Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Nature of Col E ₁ Plasmid Replication in Escherichia coli in the Presence of Chloramphenicol

1972 • 1,202 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Preservation of hamster oocytes to assay the fertilizing capacity of human spermatozoa

1982 • 653 citations

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

[49] Rapid DNA isolations for enzymatic and hybridization analysis

1980 • 572 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Effect of Growth Conditions on the Formation of the Relaxation Complex of Supercoiled ColE1 Deoxyribonucleic Acid and Protein in Escherichia coli

1972 • 351 citations

The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors

1983 • 341 citations

Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from mouse mammary tumor virus

1981 • 303 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

N-myc can cooperate with ras to transform normal cells in culture.

1985 • 184 citations

Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice

1985 • 150 citations

Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice.

1986 • 140 citations

Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.

1983 • 138 citations

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17

1987 • 122 citations

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.

1985 • 117 citations

v-mil induces autocrine growth and enhanced tumorigenicity in v-myc-transformed avian macrophages

1986 • 100 citations

Synergism of v-myc and v-Ha-ras in the in Vitro Neoplastic Progression of Murine Lymphoid Cells

1986 • 78 citations

Accomplishments in cancer research, 1984

1987 • 57 citations

Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells.

1986 • 36 citations