Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1993 • 734 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Reversal of Terminal Differentiation Mediated by p107 in Rb ^-/- Muscle Cells

1994 • 369 citations

Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

1994 • 348 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.

1995 • 346 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons

1993 • 338 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1995 • 294 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

1994 • 286 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

Essential role for p53-mediated transcription in E1A-induced apoptosis.

1995 • 219 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes

1993 • 185 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.

1996 • 154 citations

Cell Cycle Regulation of E2F Site Occupation in Vivo

1996 • 152 citations

Transcriptional regulation during the mammalian cell cycle

1995 • 152 citations

Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein

1993 • 151 citations

p53 and the Li-Fraumeni syndrome

1993 • 151 citations

The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors

1993 • 135 citations

p53 and the Li-Fraumeni syndrome

1994 • 116 citations

The retinoblastoma gene and gene product.

1992 • 111 citations

Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins.

1995 • 83 citations

A Protein Synthesis-Dependent Increase in E2F1 mRNA Correlates with Growth Regulation of the Dihydrofolate Reductase Promoter

1993 • 80 citations

Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells.

1992 • 54 citations

Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1.

1993 • 51 citations

Molecular genetics of neuronal survival

1995 • 48 citations

Influence of growth factors on neuronal differentiation

1995 • 45 citations

Neuronal cell death: searching for the smoking gun

1994 • 22 citations