Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Germline p16 mutations in familial melanoma

1994 • 1,241 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Complex structure and regulation of the P16 (MTS1) locus.

1995 • 402 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

A novel p16INK4A transcript.

1995 • 348 citations

Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

1994 • 345 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 321 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

1994 • 237 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein.

1994 • 185 citations

Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma.

1994 • 176 citations

REGULATION OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

1991 • 135 citations

Somatic Mutations of the MTS (Multiple Tumor Suppressor) 1/CDK41 (Cyclin-Dependent Kinase-4 Inhibitor) Gene in Human Primary Non-small Cell Lung Carcinomas

1994 • 122 citations

Diversity of coding strategies in influenza viruses

1991 • 75 citations

SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae.

1990 • 68 citations

Molecular Cloning, Expression Pattern, and Chromosomal Localization of Human CDKN2D/INK4d,an Inhibitor of Cyclin D-Dependent Kinases

1995 • 56 citations

Structure of the DNA Damage-Inducible Gene DDR48 and Evidence for Its Role in Mutagenesis in Sacharomyces cerevisiae

1990 • 39 citations

Non-Small-Cell Lung Carcinoma

1995 • 34 citations

Tumor Suppression: Lessons in p16 from phylum Falconium

1995 • 29 citations

Open reading frames in the antisense strands of genes coding for glycolytic enzymes in Saccharomyces cerevisiae

1994 • 28 citations

Structure of the DNA damage-inducible gene DDR48 and evidence for its role in mutagenesis in Saccharomyces cerevisiae.

1990 • 27 citations

A Novel Transcriptional Activator Originating from an Upstream Promoter in the Human Growth Hormone Gene

1995 • 13 citations