Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Practical Statistics for Medical Research

1990 • 9,667 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings

1987 • 1,036 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

1995 • 521 citations

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

1994 • 519 citations

Familial Polyposis Coli

2008 • 506 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

The Muir-Torre syndrome: A 25-year retrospect

1995 • 397 citations

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1995 • 378 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

Aberrant crypts: potential preneoplastic lesions in the murine colon.

1988 • 305 citations

Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

1994 • 287 citations

Hereditary Nonpolyposis Colorectal Cancer—Lynch Syndromes I and II

1988 • 255 citations

Inactivation of both APC alleles in human and mouse tumors.

1994 • 248 citations

The Cancer Family Syndrome Rare Cutaneous Phenotypic Linkage of Torre's Syndrome

1981 • 229 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Microsatellite instability in the progression of gastric carcinoma.

1994 • 205 citations

Microsatellite instability occurs frequently in human gastric carcinoma.

1994 • 203 citations

The tumour spectrum in hereditary non‐polyposis colorectal cancer: A study of 24 kindreds in the netherlands

1990 • 190 citations

Microsatellite instability and loss of heterozygosity in breast cancer.

1994 • 189 citations

Microsatellite instability in bladder cancer.

1993 • 187 citations

Microsatellite instability in Muir-Torre syndrome.

1994 • 180 citations

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas

1995 • 171 citations

Genetic instability of microsatellite sequences in many non-small cell lung carcinomas

1994 • 167 citations

Microsatellite Mutation (Cag24→18) in the Androgen Receptor Gene in Human Prostate Cancer

1994 • 166 citations

Hereditary non-polyposis colorectal cancer — morphologies, genes and mutations

1994 • 147 citations

Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome

1985 • 144 citations

Classification of aberrant crypt foci and microadenomas in human colon.

1991 • 142 citations

Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia [see comments]

1994 • 137 citations

Genomic instability occurs in colorectal carcinomas but not in adenomas

1993 • 135 citations

Genetic instability in human ovarian cancer cell lines.

1994 • 134 citations

Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer

1995 • 94 citations

Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin.

1995 • 86 citations

Genetic linkage in Muir-Torre syndrome to the same chromosomal region as cancer family syndrome

1994 • 76 citations

Genetic instability of microsatellites in hematological neoplasms.

1995 • 64 citations

Differential cellular expression of the human MSH2 repair enzyme in small and large intestine.

1995 • 64 citations

Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients

1995 • 59 citations

Muir-Torre syndrome: a variant of the cancer family syndrome.

1994 • 50 citations

Microsatellite instability in the progression of gastric carcinoma

1996 • 33 citations

Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome.

1995 • 31 citations

Tumor variation in three extended Lynch syndrome II kindreds.

1988 • 29 citations

Obstructive jejunal adenocarcinoma in the Muir-Torre syndrome.

1993 • 5 citations