c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Apoptosis

1993 • 972 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Oncogenic activity of the c-Myc protein requires dimerization with Max

1993 • 543 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1993 • 392 citations

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.

1985 • 370 citations

The role of c-myc in cell growth

1993 • 365 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.

1988 • 324 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact.

1986 • 254 citations

Negative autoregulation of c-myc transcription.

1990 • 247 citations

Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents.

1992 • 224 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.

1988 • 195 citations

An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

1990 • 153 citations

Augmented Mitogenesis and Impaired Metabolic Signaling Mediated by a Truncated Insulin Receptor

1989 • 109 citations

Definition of Regions in Human c-myc that are Involved in Transformation and Nuclear Localization

1987 • 106 citations

Max and c-Myc/Max DNA-binding activities in cell extracts.

1992 • 94 citations

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

1990 • 94 citations

A sensitive and quantitative enzyme-linked immunosorbence assay for the c-myc and N-myc oncoproteins.

1987 • 76 citations

Identification and characterisation of the egr-1 gene product as an inducible, short-lived, nuclear phosphoprotein.

1990 • 72 citations

C-myc and the yeast transcription factor PHO4 share a common CACGTG-binding motif.

1991 • 59 citations

Myc-Mediated Apoptosis Is Blocked by Ectopic Expression of Bcl-2

1993 • 57 citations

Selective Inhibition of Growth-Related Gene Expression in Murine Keratinocytes by Transforming Growth Factor β

1988 • 56 citations

Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells

1989 • 44 citations

Complementation by BCL2 and C-HA-RAS Oncogenes in Malignant Transformation of Rat Embryo Fibroblasts

1990 • 42 citations

c-myc Antisense Transcripts Accelerate Differentiation and Inhibit G₁ Progression in Murine Erythroleukemia Cells

1988 • 38 citations

Cell-cycle-specific induction of quiescence achieved by limited inhibition of protein synthesis: Counteractive effect of addition of purified growth factors

1985 • 31 citations

The double life of the IGF-1 receptor.

1992 • 26 citations

Domains of Human c-myc Protein Required for Autosuppression and Cooperation with ras Oncogenes Are Overlapping

1990 • 19 citations