A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Localization of the gene for familial adenomatous polyposis on chromosome 5

1987 • 1,386 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Alleles of the APC gene: An attenuated form of familial polyposis

1993 • 621 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.

1992 • 337 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma

1992 • 229 citations

Frequent somatic mutations of the APC gene in human pancreatic cancer.

1992 • 213 citations

Association between wild type and mutant APC gene products.

1993 • 194 citations

Dimer formation by an N-terminal coiled coil in the APC protein.

1993 • 175 citations

Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).

1993 • 149 citations

Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

1993 • 129 citations

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)

1992 • 120 citations

Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis

1992 • 112 citations

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis

1993 • 110 citations

Suppression with a difference

1991 • 20 citations