Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Variable Number of Tandem Repeat (VNTR) Markers for Human Gene Mapping

1987 • 1,683 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Second primary neoplasms in patients with retinoblastoma

1986 • 563 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Retinoblastoma and Subband Deletion of Chromosome 13

1978 • 455 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Gene for Hereditary Retinoblastoma Assigned to Human Chromosome 13 by Linkage to Esterase D

1983 • 369 citations

Regional Assignment of Genes for Human Esterase D and Retinoblastoma to Chromosome Band 13q14

1980 • 348 citations

Patient with 13 Chromosome Deletion: Evidence That the Retinoblastoma Gene Is a Recessive Cancer Gene

1983 • 342 citations

Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene

1988 • 270 citations

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

1988 • 247 citations

Prediction of the Risk of Hereditary Retinoblastoma, Using DNA Polymorphisms within the Retinoblastoma Gene

1988 • 242 citations

Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

1983 • 234 citations

Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology.

1988 • 137 citations

Non‐ocular cancer in patients with hereditary retinoblastoma and their relatives

1988 • 100 citations

Infrequent genomic rearrangement and normal expression of the putative RB1 gene in retinoblastoma tumors.

1988 • 74 citations

Molecular detection of chromosomal translocations that disrupt the putative retinoblastoma susceptibility locus.

1989 • 39 citations

Routine growth and differentiation of primary retinoblastoma cells in culture.

1983 • 30 citations

Infrequent Genomic Rearrangement and Normal Expression of the Putative RB1 Gene in Retinoblastoma Tumors

1988 • 17 citations