The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

1996 • 849 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

1993 • 715 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 406 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

1995 • 377 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1995 • 345 citations

Gastrulation in the mouse : Growth and regionalization of the epiblast

1977 • 340 citations

WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

1995 • 332 citations

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

1995 • 310 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 308 citations

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

1996 • 236 citations

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

1995 • 200 citations

BRCA1 is secreted and exhibits properties of a granin

1996 • 184 citations

Homozygosity for theMinallele ofApcresults in disruption of mouse development prior to gastrulation

1995 • 159 citations

Polytene chromosomes in mouse trophoblast giant cells

1988 • 135 citations

Production of completely ES cell-derived fetuses.

1993 • 132 citations

High allele loss rates at I7q I2‐q2I in breast and ovarian tumors from BRCAI‐linked families

1995 • 122 citations

Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue.

1988 • 108 citations

Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer.

1995 • 98 citations

Onset of gastrulation, morphogenesis and somitogenesis in mouse embryos displaying compensatory growth

1993 • 97 citations

Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts.

1996 • 75 citations

The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis.

1992 • 63 citations