Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 ^INK4

1995 • 382 citations

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1993 • 367 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

1995 • 339 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

Induction of cyclin D1 overexpression by activated ras.

1994 • 295 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

Regulation of the cell cycle machinery by oncogenic ras.

1996 • 202 citations

Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia.

1996 • 171 citations

The PRAD‐1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas

1994 • 160 citations

[1] Isolation and utilization of epidermal keratinocytes for oncogene research

1995 • 158 citations

Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer.

1994 • 156 citations

Chemically induced skin carcinogenesis in a transgenic mouse line (TG·AC) carrying a v-Ha-ras gene

1993 • 129 citations

Overexpression of cyclin D1 in mouse skin carcinogenesis.

1993 • 122 citations

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells

1997 • 120 citations

The D-type cyclins and their role in tumorigenesis

1994 • 116 citations

Aberrations of p16^Ink4 and retinoblastoma tumour‐suppressor genes occur in distinct sub‐sets of human cancer cell lines

1995 • 102 citations

Early overexpression of cyclin D1 protein in mouse skin carcinogenesis

1995 • 89 citations

Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras.

1997 • 81 citations

Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes.

1994 • 78 citations

The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.

1991 • 75 citations

Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin.

1994 • 69 citations

Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors

1995 • 62 citations

Focal transgene expression associated with papilloma development in v‐Ha‐ras–transgenic TG.AC mice

1994 • 57 citations

Expression of cyclin D1 and c-Ki-ras gene product in human epithelial ovarian tumors

1996 • 48 citations