Dissecting Multistep Tumorigenesis in Transgenic Mice

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

GENETICS OF HUMAN CANCER

1986 • 565 citations

The experimental study of tumor progression: a review.

1954 • 522 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression

1987 • 407 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Pancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice

1987 • 243 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Genetics of cancer predisposition.

1987 • 199 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice

1985 • 150 citations

Specific Expression of Hepatitis B Surface Antigen (HBsAg) in Transgenic Mice

1985 • 149 citations

The early region of human papovavirus JC induces dysmyelination in transgenic mice

1986 • 149 citations

Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice.

1986 • 140 citations

Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene

1987 • 140 citations

Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice.

1987 • 135 citations

Regulation of Thy-1 gene expression in transgenic mice

1987 • 131 citations

Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants.

1988 • 126 citations

Bovine papillomavirus genome elicits skin tumours in transgenic mice

1986 • 121 citations

Heart and bone tumors in transgenic mice.

1988 • 98 citations

Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice

1987 • 90 citations

c-fos expression interferes with thymus development in transgenic mice

1988 • 84 citations

Introduction of genes into the germ line of animals.

1984 • 80 citations

Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice.

1987 • 69 citations

Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen.

1987 • 69 citations

Tissue preferential expression of the hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic mice

1988 • 67 citations

Differential regulation of a Thy-1 gene in transgenic mice.

1987 • 65 citations

Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen.

1987 • 51 citations

Bidirectional activity of the rat insulin II 5'-flanking region in transgenic mice.

1987 • 51 citations

A Comparison of Several Lines of Transgenic Mice Containing the SV40 Early Genes

1985 • 49 citations

Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice.

1987 • 45 citations

Oncogenesis in Transgenic Mice

1986 • 37 citations

"Sub-threshold neoplastic states" created in transgenic mice.

1987 • 15 citations

Rearrangement of integrated HBV DNA in descendants of transgenic mice.

1986 • 11 citations