Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivo

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

p53 function and dysfunction

1992 • 1,918 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

p53 in growth control and neoplasia

1996 • 488 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Reversing Time: Origin of Telomerase

1998 • 308 citations

Increased activity of p53 in senescing fibroblasts.

1995 • 303 citations

p53-dependent apoptosis suppresses radiation–induced teratogenesis

1996 • 250 citations

Expression of p53 during mouse embryogenesis

1991 • 249 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

1996 • 171 citations

Post-translational modification of p53.

1994 • 140 citations

Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.

1995 • 120 citations

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

1985 • 117 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

p53 modulation of anchorage independent growth and experimental metastasis.

1996 • 80 citations

Alpha-Fetoprotein: 25 Years of Study

1989 • 37 citations

The properties of p53 proteins selected for the loss of suppression of transformation.

1994 • 23 citations

[Functional heterogeneity of p53-responsive elements].

1996 • 7 citations