Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Purification and cloning of amyloid precursor protein β-secretase from human brain

1999 • 1,589 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

1999 • 1,440 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1999 • 1,072 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Tau in Alzheimer's disease

1998 • 936 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand

1996 • 905 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

1998 • 845 citations

β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy

1998 • 839 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

1996 • 726 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

1992 • 725 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1999 • 701 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning

1990 • 650 citations

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

1996 • 649 citations

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1998 • 647 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

1998 • 513 citations

Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction

1996 • 503 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Laying it on thick

1999 • 471 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1989 • 463 citations

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

1993 • 460 citations

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

1994 • 445 citations

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.

1995 • 427 citations

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

1991 • 422 citations

Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation

1996 • 420 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

1998 • 401 citations

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1992 • 396 citations

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

1992 • 395 citations

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1995 • 393 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

Amyloid peptides are toxic via a common oxidative mechanism.

1995 • 372 citations

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

1999 • 369 citations

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

1997 • 367 citations

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1996 • 360 citations

Advances in Alzheimer's disease

1991 • 358 citations

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

1995 • 358 citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1999 • 355 citations

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 • 353 citations

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

1998 • 350 citations

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

1994 • 349 citations

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

1999 • 346 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1

1986 • 336 citations

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

1998 • 336 citations

Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein.

1995 • 333 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

1996 • 328 citations

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

1998 • 327 citations

Age-related spatial reference and working memory deficits assessed in the water maze

1995 • 314 citations

An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

1994 • 304 citations

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

1998 • 300 citations

Acetylcholinesterase promotes the aggregation of amyloid-β-peptide fragments by forming a complex with the growing fibrils 1 1Edited by A. R. Fersht

1997 • 287 citations

Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism

1998 • 280 citations

Role of Estrogen Replacement Therapy in Memory Enhancement and the Prevention of Neuronal Loss Associated With Alzheimer’s Disease

1997 • 280 citations

Discussion

1997 • 279 citations

Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

1996 • 268 citations

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

1996 • 265 citations

β-Amyloid protein-induced Alzheimer's disease animal model

1994 • 264 citations

Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B

1995 • 264 citations

Alzheimer's disease: a re-examination of the amyloid hypothesis

1998 • 256 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

1999 • 240 citations

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

1997 • 233 citations

Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

1989 • 233 citations

Regulation of Amyloid Precursor Protein Cleavage

1999 • 224 citations

Cerebrospinal fluid A?42 is increased early in sporadic Alzheimer's disease and declines with disease progression

1999 • 215 citations

Rapid Communication: Ca²⁺ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture

1994 • 214 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1991 • 210 citations

Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands

1997 • 209 citations

Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis.

1995 • 202 citations

Human presenilin‐1, but not familial Alzheimer’s disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1997 • 201 citations

Alzheimer's Disease: Biology, Diagnosis and Therapeutics

1998 • 201 citations

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

1998 • 199 citations

β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?

1998 • 194 citations

Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning

1992 • 183 citations

192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells

1995 • 175 citations

Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans.

1999 • 173 citations

Differential effects of amyloid peptides β-(1–40) and β-(25–35) injections into the rat nucleus basalis

1995 • 169 citations

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.

1991 • 169 citations

Amyloid β‐Peptide Inhibits High‐Affinity Choline Uptake and Acetylcholine Release in Rat Hippocampal Slices

1998 • 168 citations

Cholinergic strategies for Alzheimer's disease

1998 • 168 citations

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

1997 • 166 citations

The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease

1998 • 161 citations

Activation of the L Voltage-sensitive Calcium Channel by Mitogen-activated Protein (MAP) Kinase following Exposure of Neuronal Cells to β-Amyloid

1999 • 160 citations

Alzheimer's disease : biology, diagnosis, and therapeutics

1996 • 151 citations

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

1992 • 150 citations

Alzheimer's disease: Its proteins and genes

1988 • 149 citations

Nontoxic Amyloid β Peptide1-42 Suppresses Acetylcholine Synthesis

1997 • 149 citations

Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence

1996 • 145 citations

Continuous Infusion of .BETA.-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration.

1997 • 143 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 138 citations

Dysfunction of Cholinergic and Dopaminergic Neuronal Systems in β‐Amyloid Protein‐Infused Rats

1996 • 137 citations

Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

1995 • 132 citations

Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices.

1996 • 131 citations

The 717Val→Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

1991 • 131 citations

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice

1997 • 129 citations

Lack of alzheimer pathology after β-amyloid protein injections in rat brain

1992 • 125 citations

Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain

1989 • 125 citations

Tau protein I is essential for amyloid β-protein iduced neurotoxicity

1993 • 125 citations

Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments

1997 • 124 citations

Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation.

1999 • 123 citations

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.

1986 • 122 citations

Impairments of long-term potentiation in hippocampal slices of β-amyloid-infused rats

1999 • 119 citations

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

1999 • 119 citations

Transgenic mouse brain histopathology resembles early Alzheimer's disease

1994 • 110 citations

Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices

1996 • 110 citations

Differential Effects of Apolipoprotein E Isoforms on Metal-Induced Aggregation of Aβ Using Physiological Concentrations

1999 • 109 citations

Inhibition of fibril formation in β-amyloid peptide by a novel series of benzofurans

1999 • 105 citations

Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin

1994 • 104 citations

Learning deficits induced by chronic intraventricular infusion of quinolinic acid — protection by MK-801 and memantine

1996 • 103 citations

β-Amyloid(Phe(SO3H)24)25–35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation

1998 • 100 citations

Microtubule-associated protein tau (? ) is a major antigenic component of paired helical filaments in Alzheimer disease

1987 • 99 citations

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3β transgenes

1997 • 99 citations

Association between Alzheimer's disease and theNOS3 gene

1999 • 98 citations

From Molecular Structure to Alzheimer Therapy.

1997 • 96 citations

Memory Impairment and Neuronal Dysfunction Induced by .BETA.-Amyloid Protein in Rats.

1994 • 95 citations

Indomethacin Reverses the Microglial Response to Amyloid β-Protein

1998 • 94 citations

Mutant Presenilin 2 Transgenic Mouse: Effect on an Age-Dependent Increase of Amyloid β-Protein 42 in the Brain

1998 • 93 citations

Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction

1998 • 92 citations

Improvement by nefiracetam of β‐amyloid‐(1‐42)‐induced learning and memory impairments in rats

1999 • 91 citations

Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction

1997 • 89 citations

Present Imperfect: A Critical Review of Animal Models of the Mnemonic Impairments in Alzheimer's Disease

1997 • 87 citations

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1998 • 85 citations

Solvent effects on beta protein toxicity in vivo

1992 • 85 citations

A 12-Month, Randomized, Placebo-Controlled Trial of Propentofylline (HWA 285) in Patients with Dementia According to DSM III-R

1997 • 84 citations

Effects of an exogenous β-amyloid peptide on retention for spatial learning

1994 • 80 citations

Bilateral Injections of Amyloid-β 25-35 into the Amygdala of Young Fischer Rats: Behavioral, Neurochemical, and Time Dependent Histopathological Effects

1997 • 80 citations

β-amyloid-(1–40) increases long-term potentiation in rat hippocampus in vitro

1995 • 78 citations

Molecular Dissection of Domains in Mutant Presenilin 2 That Mediate Overproduction of Amyloidogenic Forms of Amyloid β Peptides

1998 • 77 citations

Co-injection of β-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons

1998 • 75 citations

Regulation of Amyloid Precursor Protein Secretion by Glutamate Receptors in Human Ntera 2 Neurons (NT2N)

1998 • 73 citations

The Alzheimer diseases

1996 • 72 citations

Implants containing β-amyloid protein are not neurotoxic to young and old rat brain

1992 • 71 citations

Accumulation of murine amyloidβ42 in a gene‐dosage‐dependent manner in PS1 ‘knock‐in’ mice

1999 • 68 citations

Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.

1993 • 68 citations

Progress toward valid transgenic mouse models for Alzheimer’s disease

1999 • 66 citations

The neurochemical and behavioral effects of β-amyloid peptide(25–35)

1996 • 65 citations

Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer β-amyloid fibril formation

1999 • 65 citations

Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain

1998 • 62 citations

Propentofylline improves learning and memory deficits in rats induced by β-amyloid protein-(1-40)

1998 • 62 citations

Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

1999 • 61 citations

Synthetic amyloid β-protein fails to produce specific neurotoxicity in monkey cerebral cortex

1992 • 60 citations

Chapter 48: Behavioral aspects of cholinergic transmission: role of basal forebrain cholinergic system in learning and memory

1993 • 56 citations

Intrahippocampal Injections of Exogenous β-Amyloid Induce Postdelay Errors in an Eight-Arm Radial Maze

1997 • 56 citations

Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein.

1994 • 55 citations

Long‐term deprivation of oestrogens by ovariectomy potentiates β‐amyloid‐induced working memory deficits in rats

1999 • 54 citations

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism

1999 • 51 citations

Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats

1992 • 48 citations

Proteolytic Degradation of Alzheimer's Disease Amyloid β‐Peptide by a Metalloproteinase from Microglia Cells

1998 • 45 citations

Orally active NGF synthesis stimulators: potential therapeutic agents in alzheimer's disease

1997 • 45 citations

Effects of metrifonate on memory impairment and cholinergic dysfunction in rats

1997 • 44 citations

Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats

1994 • 41 citations

Similarities between β Amyloid Peptides 1-40 and 40-1: Effects on Aggregation, Toxicity in Vitro, and Injection in Young and Aged Rats

1994 • 40 citations

Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats

1993 • 39 citations

NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats

1998 • 38 citations

Continuous Infusion of β-Amyloid Protein into the Rat Cerebral Ventricle Induces Learning Impairment and Neuronal and Morphological Degeneration

1997 • 34 citations

Oral Administration of NGF Synthesis Stimulators Recovers Reduced Brain NGF Content in Aged Rats and Cognitive Dysfunction in Basal – Forebrain – Lesioned Rats

1994 • 32 citations

Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats

1993 • 31 citations

Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction

1994 • 31 citations

Transgenic Animals in Alzheimer's Disease Research

1999 • 30 citations

Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats

1990 • 30 citations

Neurodegeneration and Gliosis in Transgenic Mice Overexpressing a Carboxy-Terminal Fragment of Alzheimer Amyloid-β Protein Precursor

1997 • 30 citations

A Putative Tetrapeptide Antagonist Prevents β-Amyloid-Induced Long-Term Elevation of [Ca2+]iin Rat Astrocytes

1997 • 29 citations

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase mos

1996 • 27 citations

Chapter 27 Amyloid β-peptides injection into the cholinergic nuclei: morphological, neurochemical and behavioral effects

1996 • 26 citations

Simulation of cortical cholinergic deficits — a novel experimental approach to study pathogenetic aspects of Alzheimer’s disease

1998 • 26 citations

Endogenous GLP-1 modulates hippocampal activity in β-amyloid protein-treated rats

1999 • 25 citations

Propionyl-IIGL tetrapeptide antagonizes β-amyloid excitotoxicity in rat nucleus basalis

1999 • 24 citations

In vivo phosphorylation in the rat basal nucleus induces PHF-like and APP immunoreactivity

1994 • 23 citations

Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody

1991 • 23 citations

Using okadaic acid as a tool for the in vivo induction of hyperphosphorylated tau

1998 • 22 citations

Perspectives of Pharmacotherapy in Alzheimer’s Disease

1999 • 21 citations

Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1–40) protein

1995 • 21 citations

Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats

1993 • 19 citations

Familial Alzheimer’s Disease

1998 • 17 citations

Acute or chronic administration of okadaic acid to rats induces brain damage rather than Alzheimer-like neuropathology

1998 • 16 citations

Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum

1996 • 15 citations

From Molecular Structure to Alzheimer Therapy

1997 • 14 citations

Fibrillogenesis of β-amyloid

1998 • 13 citations

Nefiracetam (DM‐9384): A Novel Antiamnesic Drug

1996 • 12 citations

Naftidrofuryl oxalate, nootropic effects on the scopolamine- and the basal forebrain lesion-induced amnesia in rats

1991 • 12 citations

Accumulation of murine amyloid β42 in a gene-dosage-dependent manner in PS1 'knock-in' mice

2000 • 11 citations

Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle.

1991 • 10 citations

Neuroscientific Basis of Dementia

2001 • 10 citations

Alzheimer's disease animal models induced by continuous infusion of ß-amyloid protein and anti-nerve growth factor antibody

1997 • 10 citations

569 Long-term treatment of Alzheimer's disease with idebenone

1996 • 9 citations

626 Toxicity of β-amyloid protein: Neurochemical, histological and behavioral changes

1996 • 7 citations

The neuroscientific basis of dementia

2001 • 5 citations

New therapeutic approaches to Alzheimer’s disease

2001 • 3 citations