Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein

1996 • 473 citations

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

1997 • 453 citations

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1996 • 360 citations

Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis

1997 • 351 citations

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

1998 • 329 citations

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1997 • 321 citations

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

1999 • 290 citations

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1997 • 289 citations

Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

1997 • 283 citations

A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity

1998 • 218 citations

The Alzheimer family of diseases: Many etiologies, one pathogenesis?

1997 • 218 citations

Presenilin 1 Regulates the Processing of β-Amyloid Precursor Protein C-Terminal Fragments and the Generation of Amyloid β-Protein in Endoplasmic Reticulum and Golgi

1998 • 171 citations

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.

1992 • 159 citations

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1997 • 155 citations

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1998 • 154 citations

Subcellular Distribution and Turnover of Presenilins in Transfected Cells

1998 • 147 citations

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans

1998 • 94 citations

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

1998 • 68 citations

Molecular biology of adrenergic and muscarinic cholinergic receptors

1989 • 50 citations