Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Amyloid Deposits and Amyloidosis

1980 • 1,787 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

1974 • 1,022 citations

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

1985 • 979 citations

Senile dementia of the Alzheimer type

1983 • 835 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes.

1983 • 478 citations

Dementia of the Alzheimer Type

1981 • 451 citations

Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects

1966 • 293 citations

Identification of prion amyloid filaments in scrapie-infected brain

1985 • 293 citations

The incidence of cerebral amyloid angiopathy in Alzheimer's disease

1975 • 276 citations

Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques

1983 • 173 citations

Down's syndrome

1974 • 134 citations

BrdU-33258 Hoechst analysis of DNA replication in human lymphocytes with supernumerary or structurally abnormal X chromosomes

1976 • 124 citations

Isolation of polymorphic DNA fragments from human chromosome 4

1987 • 100 citations

Partial trisomy 21

1977 • 99 citations

Senile Degenerative Brain Lesions and Dementia

1975 • 92 citations

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

1986 • 82 citations

Familial Down syndrome due to t(10;21) translocation: evidence that the Down phenotype is related to trisomy of a specific segment of chromosome 21.

1975 • 77 citations

Localisation of genetic markers and orientation of the linkage group on chromosome 19

1984 • 68 citations

Human lysosomal genes: Arylsulfatase A and ?-Galactosidase

1979 • 58 citations

A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle

1986 • 42 citations

Human chromosome 21-encoded cDNA clones

1986 • 38 citations

Isolation of polymorphic DNA segments from human chromosome 21

1985 • 38 citations

Partial trisomies of chromosome 21 in man. Two new observations due to translocations 19;21 and 4;21

1977 • 37 citations

Low levels of calpain activity in Chiroptera brain: Implications for mechanisms of aging

1986 • 30 citations

Abstracts of workshop presentations (Part 12 of 13)

1985 • 12 citations

Familial t (4;21)(q2.4;q2.2) leading to unbalanced offspring with partial duplication of 4q and of 21q without manifestations of the down syndrome

1984 • 12 citations