Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

1994 • 363 citations

Synaptic and neuritic alterations during the progression of Alzheimer's disease

1994 • 355 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]

1994 • 230 citations

Potent Inhibition of Scrapie‐Associated PrP Accumulation by Congo Red

1992 • 228 citations

Methodological variables in the assessment of beta amyloid neurotoxicity

1992 • 208 citations

β-Amyloid and the Pathogenesis of Alzheimer's Disease

1991 • 201 citations

Congo red inhibition of scrapie agent replication

1993 • 128 citations

Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

1993 • 122 citations

β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons

1991 • 103 citations

Alzheimer patients and Down patients: Cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques

1989 • 88 citations

Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques

1991 • 72 citations

Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically different amyloid fibrils.

1993 • 53 citations

Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?

1993 • 48 citations

Commentary and perspective on studies of beta amyloid neurotoxicity

1992 • 40 citations