Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans

1979 • 861 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

1994 • 604 citations

On the control of germ cell development in Caenorhabditis elegans

1981 • 593 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Protein Topology of Presenilin 1

1996 • 374 citations

A new kind of informational suppression in the nematode Caenorhabditis elegans.

1989 • 272 citations

Membrane Topology of the C. elegans SEL-12 Presenilin

1996 • 204 citations

Genetic dissection of Alzheimer disease, a heterogeneous disorder.

1995 • 179 citations

Histochemical techniques for locating Escherichia coli β-galactosidase activity in transgenic organisms

1992 • 103 citations

Genetic and phenotypic studies of hypomorphic lin-12 mutants in Caenorhabditis elegans.

1993 • 58 citations

Point Mutations in awd Which Revert the Prune/Killer of Prune Lethal Interaction Affect Conserved Residues That Are Involved in Nucleoside Diphosphate Kinase Substrate Binding and Catalysis

1995 • 41 citations

A yeast artificial chromosome contig from human chromosome 14q24 spanning the Alzheimer's disease locus AD3

1995 • 22 citations