Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Genomic sequencing.

1984 • 8,343 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Intracellular protein topogenesis

1980 • 1,378 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action.

1990 • 384 citations

A simple, rapid method for the purification of poly A+ RNA.

1988 • 382 citations

Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi.

1988 • 323 citations

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

1990 • 283 citations

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

1989 • 251 citations

One-sided polymerase chain reaction: the amplification of cDNA.

1989 • 241 citations

Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

1988 • 218 citations

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

1989 • 212 citations

A Novel mRNA of the A4 Amyloid Precursor Gene Coding for a Possibly Secreted Protein

1989 • 209 citations

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

1990 • 141 citations

THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4 PROTEIN IN SENILE PLAQUES IN ALZHEIMER'S DISEASE

1989 • 119 citations

Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells.

1985 • 94 citations

Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor

1989 • 77 citations

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

1988 • 76 citations

Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein.

1990 • 54 citations

A marginal band-associated protein has properties of both microtubule- and microfilament-associated proteins.

1989 • 53 citations

Insertions of up to 17 Amino Acids into a Region of α-Tubulin Do Not Disrupt Function In Vivo

1987 • 39 citations

Analyzing the components of microtubules: antibodies against chartins, associated proteins from cultured cells.

1985 • 31 citations