Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Notch Signaling

1995 • 1,282 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

1997 • 453 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION

1997 • 292 citations

Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos

1998 • 193 citations

Presenilins and Alzheimer's disease

1997 • 96 citations

A Notch Affair

1998 • 65 citations

Deleted Work

1955 • 0 citations