Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

Peptidergic neurones

1980 • 1,523 citations

Human Memory and the Cholinergic System

1974 • 1,378 citations

Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat

1978 • 1,282 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Efferent connections of the parabrachial nucleus in the rat

1980 • 1,187 citations

The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.

1979 • 1,184 citations

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

1967 • 1,116 citations

The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat

1981 • 966 citations

Central Catecholamine Neuron Systems: Anatomy and Physiology of the Dopamine Systems

1978 • 920 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

Activity of pallidal neurons during movement.

1971 • 734 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

A Positron-Emission Transaxial Tomograph for Nuclear Imaging (PETT)

1975 • 643 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex

1955 • 624 citations

Memory and cognitive function in man

1977 • 624 citations

The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat

1980 • 617 citations

Aspinous and sparsely-spinous stellate neurons in the visual cortex of rats contain glutamic acid decarboxylase

1978 • 549 citations

Human Serial Learning: Enhancement with Arecholine and Choline Impairment with Scopolamine

1978 • 530 citations

Basal forebrain neurons in the dementia of Parkinson disease

1983 • 526 citations

Dementia of the Alzheimer Type

1980 • 518 citations

Prevalence and Malignancy of Alzheimer Disease

1976 • 515 citations

Magnocellular nuclei of the basal forebrain project to neocortex, brain stem, and olfactory bulb. Review of some functional correlates

1975 • 482 citations

Evidence for a cholinergic projection to neocortex from neurons in basal forebrain.

1979 • 459 citations

Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations

1980 • 454 citations

Dementia of the Alzheimer Type

1981 • 451 citations

Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats

1980 • 447 citations

Physostigmine: Improvement of Long-Term Memory Processes in Normal Humans

1978 • 442 citations

Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat

1981 • 442 citations

Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type

1980 • 434 citations

Acetylcholinesterase-rich projections from the basal forebrain of the rhesus monkey to neocortex

1976 • 417 citations

Midbrain, diencephalic and cortical relationships of the basal nucleus of meynert and associated structures in primates

1976 • 415 citations

Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

1982 • 398 citations

Dementia in Parkinson disease

1979 • 384 citations

Basal Forebrain and Hypothalamic Connection to Frontal and Parietal Cortex in the Rhesus Monkey

1975 • 379 citations

Alzheimer's disease : senile dementia and related disorders

1978 • 369 citations

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

1981 • 362 citations

Afferents to the hippocampus of the rat studied with the method of retrograde transport of horseradish peroxidase

1974 • 358 citations

Behavioral and electroencephalographic effects of atropine and related compounds.

1966 • 355 citations

Dementia in Parkinson disease

1979 • 341 citations

ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?

1979 • 326 citations

The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey

1979 • 314 citations

NEUROCHEMICAL ALTERATIONS IN HUNTINGTON'S CHOREA

1980 • 285 citations

Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer

1980 • 267 citations

Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease

1981 • 266 citations

The bacteriology of chronic bronchitis.

1952 • 251 citations

Cholinergic Innervation in Neuritic Plaques

1982 • 249 citations

Acetylcholinesterase neurons in dopamine-containing regions of the brain

1975 • 222 citations

Presenile dementia in Down's syndrome

1974 • 219 citations

Hippocampal function required for nonspatial working memory

1981 • 210 citations

Effects of scopolamine, pentobarbital, and amphetamine on radial arm maze performance in the rat

1980 • 201 citations

Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex

1981 • 199 citations

Emanuel Miller. M.A. Cantab., F.R.C.P., D.P.M.

1970 • 198 citations

Effects of physostigmine and lecithin on memory in Alzheimer disease

1979 • 195 citations

Histological and neurochemical effects of fetal treatment with methylazoxymethanol on rat neocortex in adulthood

1979 • 190 citations

Relationship between plaques, tangles, and dementia in Down syndrome

1980 • 189 citations

Huntington's Dementia

1978 • 188 citations

Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients.

1981 • 186 citations

Structure-activity relations for the neurotoxicity of kainic acid derivatives and glutamate analogues

1978 • 182 citations

Immunohistochemical localization of choline acetyltransferase containing neostriatal neurons and their relationship with dopaminergic synapses

1976 • 169 citations

STUDIES ON THE COMPARATIVE ANATOMY OF THE GANGLION BASALE OF MEYNERT

1963 • 169 citations

An outline for the analysis of dementia

1977 • 150 citations

Biogenic amines in human brain in normal aging, senile dementia, and chronic alcoholism.

1980 • 140 citations

Reduced corticol choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide

1980 • 128 citations

Mental symptoms in Parkinson's disease during chronic treatment with levodopa

1976 • 121 citations

Neuropeptides in Alzheimer's disease, depression and schizophrenia

1981 • 119 citations

Ontogeny of Neurochemical Markers for Noradrenergic, GABAergic and Cholinergic Neurons in Neocortex Lesioned with Methylazoxymethanol Acetate

1980 • 111 citations

Alzheimer Degeneration in Down Syndrome

1975 • 93 citations

Alzheimer's Disease and Down's Syndrome*

1982 • 90 citations

Methylazoxymethanol Treatment of Fetal Rats Results in Abnormally Dense Noradrenergic Innervation of Neocortex

1979 • 81 citations

Hippocampal Free Amino Acids in Alzheimer's Disease

1980 • 74 citations

Serum monospecificity: A prerequisite for reliable immunohistochemical localization of neuronal markers including choline acetyltransferase

1981 • 74 citations

Microchemical pathology of the cerebral cortex in pre-senile dementias.

1964 • 72 citations

The cerebral cortex in presenil dementia

1973 • 71 citations

Neurofibrillary tangles in patients with Down's syndrome: A light and electron microscopic study

1973 • 64 citations

TOPOGRAPHY OF NEUROFIBRILLARY TANGLES AND GRANULOVACUOLES IN HIPPOCAMPI OF PATIENTS WITH DOWN'S SYNDROME: QUANTITATIVE COMPARISON WITH NORMAL AGEING AND ALZHEIMER'S DISEASE

1981 • 62 citations

Language disorder predicts familial Alzheimer's disease.

1981 • 61 citations

Somatostatin is not co-localized in cholinergic neurons innervating the rat cerebral cortex-hippocampal formation

1982 • 60 citations

Physostigmine and its effect on six patients with dementia

1981 • 45 citations

Selective retrograde labeling of cholinergic neurons with [3H]choline

1981 • 41 citations

Laminar distribution of cholinergic markers in neocortex: Effects of lesions

1981 • 37 citations

Monkey nucleus basalis is enriched with choline acetyltransferase

1982 • 21 citations

Partial Recovery of Glutamic-oxaloacetic Transaminase Activity in the Infarcted Areas of the Myocardium in Rabbits during Stimulation of Protein Synthesis

1963 • 6 citations