β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

The Biochemical Basis of Neuropharmacology.

1974 • 1,911 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

1996 • 726 citations

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

1995 • 691 citations

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

1996 • 649 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

1996 • 603 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

1997 • 543 citations

SODIUM‐DEPENDENT HIGH AFFINITY CHOLINE UPTAKE: A REGULATORY STEP IN THE SYNTHESIS OF ACETYLCHOLINE

1976 • 542 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative.

1994 • 373 citations

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1983 • 355 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

1992 • 324 citations

The Biochemical Basis of Neuropharmacology

1992 • 322 citations

Essential role of neocortical acetylcholine in spatial memory

1995 • 310 citations

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons.

1996 • 289 citations

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

1993 • 279 citations

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

1996 • 265 citations

β-Amyloid protein-induced Alzheimer's disease animal model

1994 • 264 citations

Nitric oxide stimulates Ca2+-independent synaptic vesicle release

1994 • 263 citations

Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons

1996 • 257 citations

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

1994 • 252 citations

Choline metabolism as a basis for the selective vulnerability of cholinergic neurons

1992 • 244 citations

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

1993 • 236 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

Genetics and molecular advances in Alzheimer's disease

1993 • 183 citations

Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum

1989 • 182 citations

Differential effects of amyloid peptides β-(1–40) and β-(25–35) injections into the rat nucleus basalis

1995 • 169 citations

Regulated secretion of beta-amyloid precursor protein in rat brain

1995 • 157 citations

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1995 • 156 citations

Glutamine and Glutamate in Mammals

2018 • 152 citations

Nontoxic Amyloid β Peptide1-42 Suppresses Acetylcholine Synthesis

1997 • 149 citations

Clinical Diagnosis and Management of Alzheimer's Disease

2006 • 145 citations

Dysfunction of Cholinergic and Dopaminergic Neuronal Systems in β‐Amyloid Protein‐Infused Rats

1996 • 137 citations

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gα_q/11

1997 • 134 citations

Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

1996 • 131 citations

Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices.

1996 • 131 citations

Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET.

1996 • 124 citations

Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments

1997 • 124 citations

Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices

1996 • 110 citations

Role of neurotransmission in the regulation of amyloid β-protein precursor processing

1994 • 101 citations

Brain Glutamate Metabolism: Neuronal-Astroglial Relationships

1993 • 97 citations

β‐Amyloid peptide fragment 25–35 potentiates the calcium‐dependent release of excitatory amino acids from depolarized hippocampal slices

1995 • 93 citations

Administration of amyloid β-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo

1994 • 84 citations

Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway

1996 • 83 citations

Amyloid Precursor Protein Metabolism in Primary Cell Cultures of Neurons, Astrocytes, and Microglia

1996 • 82 citations

Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

1993 • 73 citations

Phosphoinositide hydrolysis, Gαq, phospholipase C, and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and alzheimer's disease

1995 • 71 citations

Amyloid β protein-induced irreversible current in rat cortical neurones

1994 • 68 citations

Coupling of ml Muscarinic Receptors to G Protein in Alzheimer Disease

1991 • 65 citations

Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease

1987 • 64 citations

Coupling of muscarinic receptors to GTP proteins in postmortem human brain — alterations in Alzheimer's disease

1993 • 62 citations

β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease

1994 • 53 citations

Unsolved Problems in the Cholinergic Nervous System

1994 • 51 citations

Physiological levels of β-amyloid increase tyrosine phosphorylation and cytosolic calcium

1995 • 47 citations

Physiologic Levels of β‐Amyloid Activate Phosphatidylinositol 3‐Kinase with the Involvement of Tyrosine Phosphorylation

1996 • 39 citations

Changes of the phosphatidylcholine content and the number of synaptic vesicles in relation to the neurohumoral transmission in sympathetic ganglia

1976 • 29 citations

Clinical diagnosis and management of Alzheimer's disease

1996 • 11 citations

β-Amyloid1–40 inhibits electrically stimulated release of [3H]norepinephrine and enhances the internal calcium response to low potassium in rat cortex: Prevention with a free radical scavenger

1996 • 10 citations