Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

The Use of Antiavidin Antibody and Avidin-Biotin-Peroxidase Complex in Immunoperoxidase Technics

1981 • 1,067 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Mitochondria, free radicals, and neurodegeneration

1996 • 425 citations

Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation

1996 • 420 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Inhibition of PC12 cell redox activity is a specific,early indicator of the mechanism of beta-amyloid-mediated celldeath.

1994 • 406 citations

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

1995 • 401 citations

Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease

1996 • 384 citations

Amyloid peptides are toxic via a common oxidative mechanism.

1995 • 372 citations

Melatonin Prevents Death of Neuroblastoma Cells Exposed to the Alzheimer Amyloid Peptide

1997 • 363 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria

1995 • 281 citations

The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimerʼs Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution

1993 • 269 citations

Heat shock-like protein is transferred from glia to axon

1986 • 229 citations

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

1995 • 224 citations

Lack of alzheimer pathology after β-amyloid protein injections in rat brain

1992 • 125 citations

The Amyloid β Protein Induces Oxidative Damage of Mitochondrial DNA

1997 • 106 citations

Ubiquitin-protein conjugates in Alzheimer's lesions

1987 • 97 citations

Processing of Alzheimer's Amyloid Precursor Protein during H2O2-Induced Apoptosis in Human Neuronal Cells

1997 • 94 citations

Failure of beta-amyloid protein fragment 25–35 to cause hippocampal damage in the rat

1992 • 72 citations

Ubiquitin, cell stress and diseases of the nervous system

1990 • 68 citations

Synthetic amyloid β-protein fails to produce specific neurotoxicity in monkey cerebral cortex

1992 • 60 citations

The genesis of the senile plaque. Further evidence in support of its neuronal origin.

1992 • 34 citations

Accumulation of ubiquitinated proteins in mouse neuronal cells induced by oxidative stress.

1997 • 34 citations

The heat shock/oxidative stress connection

1996 • 31 citations

NEUROTOXICITY OF BETA‐AMYLOID PROTEIN: CYTOCHEMICAL CHANGES AND APOPTOTIC CELL DEATH INVESTIGATED IN ORGANOTYPIC CULTURES

1995 • 18 citations