Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

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1996 • 4,118 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

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1996 • 956 citations

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1997 • 884 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

1995 • 554 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

1997 • 388 citations

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 • 353 citations

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease

1996 • 346 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma

1996 • 316 citations

An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

1994 • 304 citations

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α₂‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

1995 • 297 citations

The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

1993 • 295 citations

α₂‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein

1997 • 259 citations

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

1989 • 251 citations

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

1992 • 231 citations

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

1994 • 214 citations

Amyloid β protein (Aβ) removal by neuroglial cells in culture

1995 • 182 citations

Amyloid β‐Peptide Induces Cell Monolayer Albumin Permeability, Impairs Glucose Transport, and Induces Apoptosis in Vascular Endothelial Cells

1997 • 171 citations

Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

1997 • 166 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

1997 • 164 citations

Scavenging of Alzheimer's amyloid ?-protein by microglia in culture

1996 • 160 citations

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.

1992 • 158 citations

Biochemical Characterization of Alzheimer's Soluble Amyloid Beta Protein in Human Cerebrospinal Fluid: Association with High Density Lipoproteins

1996 • 131 citations

Rodent models of Alzheimer's disease: Rat aβ infusion approaches to amyloid deposits

1996 • 131 citations

α1-Antitrypsin and α1-antichymotrypsin are in the lesions of Alzheimerʼs disease

1992 • 128 citations

Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells

1995 • 126 citations

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells

1997 • 110 citations

Lipofuscin-Like Substances Accumulate Rapidly in Brain, Retina and Internal Organs with Cysteine Protease Inhibition

1990 • 100 citations

The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.

1994 • 99 citations

Cathepsin D is involved in the clearance of Alzheimer's β‐amyloid protein

1996 • 92 citations

Preferential deposition of amyloid β protein (Aβ) in the form Aβ40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele

1997 • 92 citations

Aβ1–40 but not Aβ1–42 levels in cortex correlate with apolipoprotein E ϵ4 allele dosage in sporadic Alzheimer's disease

1997 • 88 citations

A Possible Role for Cathepsins D, E, and B in the Processing of β‐amyloid Precursor Protein in Alzheimer's Disease

1997 • 87 citations

Solvent effects on beta protein toxicity in vivo

1992 • 85 citations

Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

1994 • 79 citations

Human and rodent sequence analogs of Alzheimer's amyloid βA4 share similar properties and can be solubilized in buffers of pH 7.4

1991 • 78 citations

Lysosome instability in aged rat brain

1989 • 71 citations

Lack of long-term effects after β-amyloid protein injections in rat brain

1994 • 69 citations

Accumulation of amyloid precursor fragment in Alzheimer plaques

1991 • 67 citations

Degradation of Alzheimerʼs β-amyloid protein by human cathepsin D

1996 • 65 citations

Anomalous accumulation of τ and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

1989 • 65 citations

Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid β-protein

1989 • 64 citations

Microglial Response to Transient Focal Cerebral Ischemia: An Immunocytochemical Study on the Rat Cerebral Cortex Using Anti-Phosphotyrosine Antibody

1994 • 61 citations

Specific Increase in Amyloid β-Protein 42 Secretion Ratio by Calpain Inhibition

1997 • 60 citations

Rapid cellular uptake of Alzheimer amyloid βA4 peptide by cultured human neuroblastoma cells

1996 • 50 citations

Monoclonal antibody to the C-terminus of β-amyloid

1994 • 43 citations

β-Amyloid Peptide Produced in Vitro Is Degraded by Proteinases Released by Cultured Cells

1995 • 41 citations

An Endosomal‐Lysosomal Pathway for Degradation of Amyloid Precursor Protein ^a

1992 • 33 citations

β-amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin

1994 • 29 citations

Chloroquine administration in mice increases β-amyloid immunoreactivity and attenuates kainate-induced blood–brain barrier dysfunction

1997 • 24 citations

Serpins Inhibit the Toxicity of Amyloid Peptides

1997 • 23 citations

Reduction of Plasma Glutamyl Aminopeptidase Activity in Sporadic Alzheimer's Disease

1997 • 23 citations

Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin

1995 • 11 citations

Enhanced aggregation of β-amyloid-containing peptides by extracellular matrix and their degradation by the 68 kDa serine protease prepared from human brain

1996 • 10 citations

Abnormal sequestation of lysosomal hydrases in Aβ mediated neurotoxicity.

1997 • 8 citations

Neurochemical and Pathological Alterations following Infusion of Leupeptin, a Protease Inhibitor, into the Rat Brain

1996 • 8 citations

Special issue: Is beta-amyloid neurotoxic?

1992 • 3 citations